"PLAT" Related Products

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Human PLAT Stable Cell Line-CHO

Cat.No.: CSC-TP025
Product Overview: CHO-Human ITissue plasminogen activator Stable Cell Line(Tenecteplase) is clonally-derived from a CHO cell line, which has been transfected with an PLAT gene which has a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain.
Description: This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. The expression product is the active ingredient of TNKase, Activase and Retavase.
Source: CHO
Species: Human
Molecular Mass: 59.0 kDa
Protein length: 527 aa
Endotoxin: < 1.0 EU per μg of the protein
Purity: >95%
Notes: Growth Properties: Adherent;
Morphology: Epithelial-like.
Gene Name: PLAT plasminogen activator, tissue [ Homo sapiens ]
Official Symbol: PLAT
Synonyms: PLAT; plasminogen activator, tissue; tissue-type plasminogen activator; alteplase; reteplase; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA); TPA; T-PA; DKFZp686I03148;
Gene ID: 5327
mRNA Refseq: NM_000930
Protein Refseq: NP_000921
MIM: 173370
UniProt ID: P00750
Chromosome Location: 8p11.21
Pathway: Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Dissolution of Fibrin Clot, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function: peptidase activity; protein binding; serine-type endopeptidase activity; serine-type endopeptidase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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