"F7" Related Products

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Human F7 Stable Cell Line-CHO

Cat.No.: CSC-TP026
Product Overview: CHO-Human Coagulation Factor VII Stable Cell Line(Coagulation factor VIIa) is clonally-derived from a CHO cell line, which has been transfected with an F7 gene to allow expression of the Human Coagulation Factor VII.
Description: This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy. The expression product is the active ingredient of Novoseven and Niastase.
Source: CHO
Species: Human
Molecular Mass: 45.1 kDa
Protein length: 406 aa
Endotoxin: < 1.0 EU per μg of the protein
Purity: >95%
Notes: Growth Properties: Adherent;
Morphology: Epithelial-like.
Gene Name: F7 coagulation factor VII (serum prothrombin conversion accelerator) [ Homo sapiens ]
Official Symbol: F7
Synonyms: F7; coagulation factor VII (serum prothrombin conversion accelerator); coagulation factor VII; eptacog alfa; factor VII; FVII coagulation protein; SPCA; proconvertin; serum prothrombin conversion accelerator;
Gene ID: 2155
mRNA Refseq: NM_000131
Protein Refseq: NP_000122
MIM: 613878
UniProt ID: P08709
Chromosome Location: 13q34
Pathway: BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Extrinsic Pathway, organism-specific biosystem;
Function: calcium ion binding; glycoprotein binding; peptidase activity; receptor binding; serine-type endopeptidase activity; serine-type peptidase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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