"CSF2" Related Products

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Human CSF2 Stable Cell Line-CHO

Cat.No.: CSC-TP040
Product Overview: CHO-Human Colony Stimulating Factor 2 Stable Cell Line(Sargramostim) is clonally-derived from a CHO cell line, which has been transfected with an CSF2 gene to allow expression of the CSF2, substitution of Leu23 leading to a difference from native protein.
Description: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. The expression product is the active ingredient of Immunex, Leucomax and Leukine.
Source: CHO
Species: Human
Molecular Mass: 14.4 kDa
Protein length: 127 Aa
Endotoxin: < 1.0 EU per μg of the protein
Purity: >97%
Notes: Growth Properties: Adherent;
Morphology: Epithelial-like.
Gene Name: CSF2 colony stimulating factor 2 (granulocyte-macrophage) [ Homo sapiens ]
Official Symbol: CSF2
Synonyms: CSF2; colony stimulating factor 2 (granulocyte-macrophage); granulocyte-macrophage colony-stimulating factor; GM CSF; GMCSF; granulocyte macrophage colony stimulating factor; molgramostin; sargramostim; CSF; colony-stimulating factor; granulocyte-macrophage colony stimulating factor; MGC131935; MGC138897;
Gene ID: 1437
mRNA Refseq: NM_000758
Protein Refseq: NP_000749
MIM: 138960
UniProt ID: P04141
Chromosome Location: 5q23-q31
Pathway: Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function: cytokine activity; granulocyte macrophage colony-stimulating factor receptor binding; growth factor activity; protein binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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