"LHB" Related Products

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Human LHB Stable Cell Line-Yeast

Cat.No.: CSC-TP076
Product Overview: Yeast-Human Luteinizing Hormone Stable Cell Line(Luveris) is clonally-derived from a yeast cell line, which has been transfected with an LH gene to allow expression of a recombinant human luteinizing hormone with 2 subunits, alpha = 92 residues, beta = 121 residues.
Description: This gene is a member of the LHB family and encodes the beta subunit of luteinizing hormone (LH). LHB is heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LHB is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. The expression product is the active ingredient of Luveris.
Source: Yeast
Species: Human
Molecular Mass: 30kDa
Endotoxin: < 1.0 EU per μg of the protein
Purity: >96%
Notes: Growth Properties: Suspension;
Morphology: Epithelial-like.
Storage: Can be stored at +4 centigrade short term (1-2weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoidrepeated freezing and thawing cycles.
Gene Name: LHB luteinizing hormone beta polypeptide [ Homo sapiens ]
Official Symbol: LHB
Synonyms: LHB; luteinizing hormone beta polypeptide; lutropin subunit beta; CGB4; hLHB; interstitial cell stimulating hormone; beta chain; LSH B; luteinizing hormone beta subunit; lutropin; LSH-beta; lutropin beta chain; interstitial cell stimulating hormone, beta chain; LSH-B;
Gene ID: 3972
mRNA Refseq: NM_000894
Protein Refseq: NP_000885
UniProt ID: P01229
Chromosome Location: 19q13.3
Pathway: Androgen biosynthesis, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Glycoprotein hormones, organism-specific biosystem; GnRH signaling pathway, organism-specific biosystem;
Function: hormone activity; receptor binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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