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Recombinant Pasteurella multocida toxin

Cat.No. : toxA-143P
Product Overview : This product is derived from a recombinant ToxA with His6-tag at N-termina expressed in E. coli. Its molecular weight is 145 kDa.
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Description : Pasteurella multocida toxin (PMT) is produced by a gram-negative bacillus, Pasteurella multocida. PMT activates the Gq and G12/13 dependent signaling pathways. Gq and G12/13 are alpha subunits of the GTP trimer bound protein of animal cells. It does not activate the highly related G11-dependent pathways. This toxin binds to a ganglioside-type cell surface receptor, acts intracellularly after having been internalized through an endocytic pathway, and has pleiotropic effects on cell physiology. Therefore it does not function on receptor-deficient cells or cells defective in the endocytosis pathway. PMT is encoded by the toxA gene of P. multocida.
Source : E. coli
Species : Pasteurella multocida
Tag : His
Form : 50% glycerol, 5mM Tris-HCl(pH7.5), 0.1M NaCl
Purity : More than 90% purity by SDS-PAGE (CBB staining)
Applications : 1) For the studies on the GTP trimer bound protein- dependent signaling pathway 2) As a PMT antigen for immunological assays such as ELISA, western blotting and dot blotting.
Storage : Shipped at 4℃ or -20℃ and stored at -20℃ or below
Concentration : 370 μg/ml

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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