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Recombinant Human CES2, MYC/DDK-tagged

Cat.No. : CES2-1141H
Product Overview : Recombinant Human CES2, fused with C-terminal MYC/DDK, was expressed in HEK293 Cells.
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Source : HEK293 cells
Species : Human
Tag : MYC/DDK
Molecular Mass : 68.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : CES2 carboxylesterase 2 [ Homo sapiens (human) ]
Official Symbol : CES2
Synonyms : CES2; carboxylesterase 2; iCE; CE-2; PCE-2; CES2A1; cocaine esterase; carboxylesterase 2 (intestine, liver); hCE-2; intestinal carboxylesterase; liver carboxylesterase-2; methylumbelliferyl-acetate deacetylase 2; NP_003860.2; EC 3.1.1.1; EC 3.1.1.56; EC 3.1.1.84; NP_932327.1
Gene ID : 8824
mRNA Refseq : NM_003869
Protein Refseq : NP_003860
MIM : 605278
UniProt ID : O00748
Chromosome Location : 16q22.1
Pathway : Drug metabolism - other enzymes; E2F transcription factor network; Fluoropyrimidine Activity; Phase I, non P450
Function : carboxylic ester hydrolase activity; methylumbelliferyl-acetate deacetylase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary role of CES2 in drug metabolism? 06/23/2023

CES2, a carboxylesterase enzyme, is crucial in metabolizing various drugs by hydrolyzing ester and amide bonds.

How do genetic variations in CES2 affect drug efficacy and safety? 10/29/2022

Genetic variations in CES2 can lead to differences in drug metabolism, influencing treatment outcomes.

How does CES2 interact with other enzymes in the liver and gastrointestinal tract? 07/12/2022

CES2 collaborates with other metabolic enzymes, playing a role in the body's overall drug-processing capacity.

What role does CES2 play in the absorption and activation of prodrugs? 05/22/2022

CES2 is involved in activating prodrugs in the intestine, affecting their absorption and therapeutic action.

What potential therapeutic applications arise from targeting CES2 in personalized medicine? 10/24/2020

Understanding CES2 activity could aid in developing personalized treatment plans, optimizing drug efficacy and safety.

What is the impact of altered CES2 activity on pharmacokinetics? 10/12/2019

Altered CES2 activity can significantly affect the pharmacokinetics of drugs, altering their efficacy and toxicity.

How does CES2 contribute to the breakdown of ester and amide bonds in medications? 03/26/2018

It helps in the breakdown of drugs, facilitating their conversion into active or inactive metabolites.

Customer Reviews (3)

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Reviews
10/12/2022

    Exceptional support. Accelerates research timelines.

    05/03/2020

      Critical for research integrity. Integral to experiments.

      04/14/2020

        Timely and precise. Trusted for research milestones.

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