Recombinant Human VWF, DDK-tagged
Cat.No. : | VWF-2714H |
Product Overview : | Recombinant human VWF, was expressed in sf9 cells, Met-Ser764-Ser1263, with C-terminal DDK tag. |
- Specification
- Gene Information
- Related Products
Description : | The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. |
Source : | sf9 cells |
Species : | Human |
Tag : | DDK |
Form : | 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol. |
Molecular Mass : | 55 kDa |
Protein length : | Met-Ser764-Ser1263 |
Purity : | >80% as determined by SDS-PAGE and Coomassie blue staining |
Storage : | Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions. |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | VWF von Willebrand factor [ Homo sapiens ] |
Official Symbol : | VWF |
Synonyms : | VWD; F8VWF; von Willebrand factor; coagulation factor VIII VWF |
Gene ID : | 7450 |
mRNA Refseq : | NM_000552 |
Protein Refseq : | NP_000543 |
MIM : | 613160 |
UniProt ID : | P04275 |
Chromosome Location : | 12p13.3 |
Pathway : | Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem |
Function : | chaperone binding; collagen binding; glycoprotein binding |
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VWF-2543H | Recombinant Human VWF protein(1491-1900 aa), C-His-tagged | +Inquiry |
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VWF-18420M | Recombinant Mouse VWF Protein, His tagged | +Inquiry |
◆ Native Protein | ||
VWF-369H | Native Human Von Willebrand Factor | +Inquiry |
VWF-17H | Native Human von Willebrand Factor, Factor VIII Free | +Inquiry |
◆ Lysates | ||
VWF-001HCL | Recombinant Human VWF cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThere is currently no treatment that directly targets the VWF protein. However, some medications can improve the patient's clotting status and reduce the risk of bleeding. For example, the use of recombinant human coagulation factor VIII. can replace the deficient factor VIII and improve coagulation function. In addition, the use of antifibrinolytic drugs can inhibit the degradation of fibrin and maintain the stability of the coagulation process.
VWF protein is closely related to coagulation factor VIII. Coagulation factor VIII. is a serine protease that plays a key role in the coagulation process. VWF protein can act as a cofactor for coagulation factor VIII., accelerating the coagulation process. In addition, VWF protein can also inhibit the activity of plasminogen activators, thereby inhibiting the degradation of fibrin and maintaining the stability of the coagulation process.
In the process of hemostasis, the role of VWF protein is mainly to promote platelet adhesion and aggregation. When platelets bind to VWF protein, morphological changes occur and the phospholipid surface is exposed, which interacts with other platelets or endothelial cells to form platelet thrombosis and play a hemostatic role.
There is a complex interaction between VWF protein and other coagulation factors. For example, VWF proteins can bind to glycoprotein II.b/III.a receptors on the surface of platelets, promoting platelet adhesion and aggregation.
Genetic variations in the VWF protein can lead to coagulation disorders such as von Willebrand disease (VWD). Some variants can cause VWF protein deficiency or dysfunction, which can affect the ability of platelets to adhere and aggregate, increasing the risk of bleeding. Understanding these variants can help diagnose and classify different subtypes of VWD.
The main function of VWF protein in blood is to promote platelet adhesion and aggregation, thereby participating in the process of hemostasis and coagulation. In addition, VWF protein can also act as a regulator of endothelial cells and participate in the repair and remodeling of blood vessel walls.
Customer Reviews (3)
Write a reviewStrong activity, a small amount can play a role, save reagents.
It has been used in experiments, and the results are accurate and reliable.
No significant difference was found between different batches, and the repeatability between batches was good.
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