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Recombinant Human AGR2, His-tagged

Cat.No. : AGR2-63H
Product Overview : Recombinant Human Anterior Gradient Homolog 2 fused to His-tag on N-terminal produced inE.Coliis a single, non-glycosylated polypeptide chain containing 192 amino acids (21-175) & having a molecular mass of 22 kDa.
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Cat. No. : AGR2-63H
Description : AGR2 (Anterior gradient 2 homolog) is the human orthologue of the secreted Xenopus laevis Anterior Gradient protein (XAG-2). This is a small, possibly secreted molecule of yet weakly defined functions that is widely expressed in human tissues. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of EGF receptor.
Source : Escherichia Coli.
Sequence : MRGSHHHHHHGMASMTGGQQMGRDL YDDDDKDRWGSMRDTTVKPGAKKDK DSRPKLPQTLSRGWGDQLIWTQTYE EALYKSKTSNKPLMIIHHLDECPHS QAL KKVFAENKEIQKLAEQFVLLNLVYE TTDKHLSPDGQ YVPRIMFVDPSLTVRADITGRYSNR LYAYE PADTALLLDNMKKALKLLKTEL
Physical Appearance : Sterile filtered clorless solution.
Purity : Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : The protein (1mg/ml) contains 1X PBS pH-7.4
Applications : • ELISA • MS • Inhibition Assays • Western Blotting
Storage : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles
Gene Name : anterior gradient homolog 2 (Xenopus laevis) [ Homo sapiens ]
Synonyms : AG2; GOB-4; HAG-2; XAG-2; PDIA17; AGR2; anterior gradient 2 homolog; secreted cement gland homolog; protein disulfide isomerase family A, member 17; Anterior gradient protein 2 homolog; hAG-2; AG-2; Secreted cement gland protein XAG-2 homolog; HPC8; UNQ515/PRO1030
Gene ID : 10551
mRNA Refseq : NM_006408
Protein Refseq : NP_006399
MIM : 606358
UniProt ID : O95994
Chromosome Location : 7p21.3
Function : protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Does AGR2 expression correlate with patient prognosis? 03/19/2022

High levels of AGR2 expression have been associated with poorer prognosis in several types of cancer, indicating its potential as a prognostic biomarker.

How does AGR2 contribute to cancer metastasis? 02/10/2022

AGR2 promotes cancer cell migration and invasion by modulating signaling pathways involved in epithelial-to-mesenchymal transition (EMT) and extracellular matrix remodeling.

What is the function of AGR2? 06/12/2021

AGR2 has been implicated in protein folding, quality control, and secretion of other proteins. It is also involved in cancer progression and metastasis.

What is the role of AGR2 in endoplasmic reticulum (ER) stress? 11/10/2020

AGR2 is upregulated in response to ER stress and helps restore ER homeostasis by promoting protein folding and reducing ER stress-induced apoptosis.

How is AGR2 involved in protein folding and quality control? 03/19/2020

AGR2 acts as a chaperone protein, facilitating the correct folding of secretory proteins and assisting in their quality control before secretion.

Are there any inhibitors or modulators of AGR2? 03/12/2020

Several small molecules and antibodies targeting AGR2 have been developed as potential therapeutic agents, but further research is needed to validate their efficacy.

Are there any AGR2-related genetic polymorphisms associated with disease? 01/29/2020

Some genetic variants in the AGR2 gene have been associated with an increased risk of certain cancers, including prostate and breast cancer.

What role does AGR2 play in cancer? 07/20/2019

AGR2 is overexpressed in various cancers, including breast, prostate, lung, and ovarian cancers, and has been associated with tumor growth, invasion, and drug resistance.

What are the downstream signaling pathways regulated by AGR2? 10/22/2018

AGR2 can activate signaling pathways such as the PI3K/AKT pathway, Wnt/β-catenin pathway, and MAPK/ERK pathway, which are involved in cell survival, proliferation, and migration.

Can AGR2 be used as a diagnostic marker for cancer? 05/21/2018

Yes, elevated levels of AGR2 have been detected in the blood and tissue samples of cancer patients, making it a potential biomarker for cancer diagnosis.

Customer Reviews (5)

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Reviews
05/13/2022

    Very impressed.

    02/26/2020

      Excellent value for its price

      02/15/2020

        The customer support was also excellent, providing prompt assistance when needed.

        01/28/2018

          The customer service was responsive and assisted me with technical questions.

          01/01/1900

            The purity and activity of the protein were exceptional, and it worked perfectly in my experiments.

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