Active Recombinant Human JAG2, Fc Chimera

• Cat.No.: JAG2-229H
• Product Overview: Recombinant Human JAG2 (Accession # AAB84215) was produced in Chinese Hamster Ovary cell line, CHO-derived.

Specification

• Source: CHO cells
• Species: Human
• Tag: Fc Chimera
• Predicted N Terminal: Met27
• Form: Lyophilized from a 0.2 µm filtered solution in PBS and EDTA.
• Bio-activity: Measured by the ability of the immobilized protein to enhance BMP-2 induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. Nobta, M. et al. (2005) J. Biol. Chem. 280:15842.The ED50 for this effect is typically 0.5-2 µg/mL.
• Molecular Mass: Recombinant Human JAG2, Fc Chimera has a calculated MW of 138.7 kDa (monomer). In SDS-PAGE migrates as 165-175 kDa, reducing conditions.
• Purity: >85%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
• Publication:
  The Special Role of JAK/STAT, and Notch Signaling Pathways in Cancer Pathogenesis (2023)

Gene Information

• Gene Name: JAG2 jagged 2 [ Homo sapiens ]
• Official Symbol: JAG2
• Synonyms: JAG2; jagged 2; protein jagged-2; HJ2; SER2
• Gene ID: 3714
• mRNA Refseq: NM_002226
• Protein Refseq: NP_002217
• MIM: 602570
• UniProt ID: Q9Y219
• Chromosome Location: 14q32