Active Recombinant Cotton Rat Il1a
Cat.No. : | Il1a-380C |
Product Overview : | Recombinant Cotton Rat Il1a (Accession # AAK94011) Ser115-Pro269 was produced in E. coli-derived. |
- Specification
- Gene Information
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Source : | E. coli |
Species : | Cotton Rat |
Predicted N Terminal : | Ser115 |
Form : | Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein. |
Bio-activity : | Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 272.The ED50 for this effect is typically 1 - 5 pg/mL |
Molecular Mass : | Recombinant Cotton Rat Il1a has a calculated MW of 17.7 kDa. |
Purity : | >95%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Reconstitution : | Reconstitute at 10 µg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
Gene Name : | Il1a interleukin 1 alpha [ Rattus norvegicus (Norway rat) ] |
Official Symbol : | Il1a |
Synonyms : | Il1a; interleukin 1 alpha; IL-1 alpha; interleukin-1 alpha |
Gene ID : | 24493 |
mRNA Refseq : | NM_017019 |
Protein Refseq : | NP_058715 |
MIM : | |
UniProt ID : | P16598 |
Chromosome Location : | 3q36 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionCross-talk between IL-1α's and other cytokines is dissected through methods such as co-immunoprecipitation, ELISA, and cytokine profiling arrays.
IL-1α's paradoxical roles are dissected using conditional knockout mice, 3D culture systems, and molecular analyses to delineate context-specific effects.
Single-cell RNA sequencing uncovers heterogeneity in IL-1α-responsive cell populations and their roles, revealing distinct molecular profiles and functions.
IL-1α's intricate pro-inflammatory signaling pathways are decoded using advanced techniques like mass spectrometry, phosphoproteomics, and bioinformatics.
Genetic editing tools like CRISPR-Cas9 unveil IL-1α's contributions to diseases by generating knockout models and studying resulting phenotypic changes.
In vitro co-culture systems are manipulated to study IL-1α-mediated responses, elucidating immune-stromal cell interactions via cytokine-specific neutralization.
Specific cellular receptors and effectors influenced by IL-1α are identified through techniques like co-immunoprecipitation, ChIP-seq, and siRNA knockdown.
Live-cell microscopy captures real-time IL-1α release dynamics and its impact on neighboring cells, facilitated by fluorescent tagging and high-resolution imaging.
Longitudinal studies and statistical modeling establish the quantitative relationship between IL-1α levels and disease progression, offering predictive insights.
Multi-omics analyses provide a holistic view of IL-1α signaling's impact, integrating transcriptomics, proteomics, and metabolomics data for comprehensive insights.
Customer Reviews (3)
Write a reviewHigh solubility.
Good for intracellular staining.
Effective in apoptosis assays.
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