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Active Recombinant Mouse Il17f, Met-tagged

Cat.No. : Il17f-403M
Product Overview : Recombinant Mouse Il17f (Accession # AAM77568) Arg21-Ala153, fused with an N-terminal Met, was produced in E. coli-derived.
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  • Gene Information
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Source : E. coli
Species : Mouse
Predicted N Terminal : Met
Form : Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Bio-activity : Measured by its ability to bind mouse IL-17 RC in a functional ELISA with an estimated KD < 3 nM. Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. Yao, Z. et al. (1995) Immunity 3:811.The ED50 for this effect is typically 20-120 ng/mL.
Molecular Mass : Recombinant Mouse Il17f, Met-tagged has a calculated MW of 15 kDa (monomer). In SDS-PAGE migrates as 16 kDa, reducing conditions.
Purity : >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Reconstitution : Reconstitute at 100 µg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Gene Name : Il17f interleukin 17F [ Mus musculus ]
Official Symbol : Il17f
Synonyms : IL17F; interleukin 17F; interleukin-17F; C87042; IL-17F;
Gene ID : 257630
mRNA Refseq : NM_145856
Protein Refseq : NP_665855
MIM :

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What techniques are used to assess IL17F's involvement in cancer development and its potential as a therapeutic target? 03/05/2022

Tumor xenografts, immune cell infiltration analysis, and therapeutic antibody testing assess IL17F's role in cancer.

What methodologies are employed to explore IL17F's role in promoting neutrophil recruitment and activation at mucosal sites? 04/05/2021

Neutrophil chemotaxis assays, in vivo neutrophil tracking, and immune cell activation analysis explore IL17F's impact on neutrophil functions.

How do researchers differentiate the functional roles of IL17F from other IL17 family members in immune responses? 02/04/2021

Genetic knockout models, functional assays, and gene expression analyses distinguish IL17F's unique roles.

How is the interplay between IL17F and gut microbiota investigated, and what are the implications for intestinal health? 07/21/2020

Microbiota composition analysis, germ-free models, and immune cell profiling investigate IL17F-microbiota interactions.

Could you elaborate on the strategies employed to investigate IL17F's contribution to autoimmune diseases using experimental models and patient samples? 05/27/2020

Animal disease models, patient samples, and immunological assays elucidate IL17F's contribution to autoimmune diseases.

What experimental techniques are utilized to dissect the complex heterodimerization of IL17F with IL17A and its impact on signaling pathways? 04/09/2020

Co-immunoprecipitation, fluorescence resonance energy transfer (FRET), and pathway-specific assays elucidate IL17F's heterodimerization and signaling.

How do researchers investigate the potential synergistic or antagonistic effects of IL17F on tissue inflammation in comparison to other cytokines? 12/21/2019

Comparative cytokine profiling, inflammatory assays, and pathway analysis dissect IL17F's interplay with other immune mediators.

What molecular approaches are used to study IL17F's involvement in chronic inflammatory conditions, such as asthma and inflammatory bowel diseases? 03/31/2018

Allergen challenges, inflammatory disease models, and gene expression profiling probe IL17F's involvement in chronic conditions.

Can you explain the experimental designs used to study the impact of IL17F on barrier function in epithelial tissues? 06/24/2017

Epithelial barrier permeability assays, tissue section analysis, and cell culture models study IL17F's effects on barrier integrity.

How do researchers explore the effects of IL17F modulation on tissue repair and regeneration in experimental models? 03/21/2017

Wound healing assays, tissue regeneration models, and histological analyses examine IL17F's effects on tissue repair.

Customer Reviews (3)

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Reviews
11/01/2022

    High specificity.

    02/23/2020

      Good for receptor studies.

      02/05/2018

        Potent in anti-bacterial assays.

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