Active Recombinant Mouse Mpl, Fc Chimera

• Cat.No.: Mpl-496M
• Product Overview: Recombinant Mouse Mpl (Accession # CAA52031) was produced in Mouse myeloma cell line, NS0-derived.

Specification

• Source: Mammalian cells
• Species: Mouse
• Tag: Fc Chimera
• Predicted N Terminal: Met
• Form: Lyophilized from a 0.2 µm filtered solution in PBS and EDTA.
• Bio-activity: Measured by its ability to inhibit the Tpo-dependent proliferation of MO7e human megakaryocytic leukemic cells.The ED50 for this effect is typically 0.1-0.4 µg/mL in the presence of 4 ng/mL of Recombinant Mouse Thrombopoietin/Tpo.
• Molecular Mass: Recombinant Mouse Mpl, Fc Chimera has a calculated MW of 79.6 kDa (monomer). In SDS-PAGE migrates as 95-110 kDa, reducing conditions.
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).

Gene Information

• Gene Name: Mpl myeloproliferative leukemia virus oncogene [ Mus musculus ]
• Official Symbol: Mpl
• Synonyms: MPL; myeloproliferative leukemia virus oncogene; thrombopoietin receptor; proto-oncogene c-Mpl; myeloproliferative leukemia protein; CD110; TPO-R; c-mpl; hlb219; c-mpl-I; c-mpl-II
• Gene ID: 17480
• mRNA Refseq: NM_001122949
• Protein Refseq: NP_001116421