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Active Recombinant Human AOC1, His-tagged

Cat.No. : AOC1-500H
Product Overview : Recombinant Human AOC1 (Accession # CAA55046) Glu20-Val751, fused with a N-terminal 6-His tag, was produced in Spodoptera frugiperda, Sf 21 (baculovirus)-derived.
  • Specification
  • Gene Information
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Source : Baculovirus Sf 21 Insect cells
Species : Human
Tag : His
Predicted N Terminal : Inconclusive, His predicted. Protein identity confirmed by MS analysis of tryptic fragments.
Form : Supplied as a 0.2 µm filtered solution in HEPES, NaCl, Glycerol.
Bio-activity : Measured by its ability to produce hydrogen peroxide during the oxidation of histamine.The specific activity is >115 pmol/min/µg, as measured under the described conditions.
Molecular Mass : Recombinant Human AOC1, His-tagged has a calculated MW of 84 kDa. In SDS-PAGE migrates as 83-92 kDa, reducing conditions.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name : AOC1 amine oxidase, copper containing 1 [ Homo sapiens (human) ]
Official Symbol : AOC1
Synonyms : AOC1; amine oxidase, copper containing 1; ABP; DAO; KAO; ABP1; DAO1amiloride-sensitive amine oxidase [copper-containing]; amiloride binding protein 1 (amine oxidase (copper-containing)); amiloride-binding protein 1; amiloride-sensitive amine oxidase; amine oxidase copper domain-containing protein 1; diamine oxidase; histaminase; kidney amine oxidase; NP_001082.2; EC 1.4.3.22; NP_001259001.1
Gene ID : 26
mRNA Refseq : NM_001091
Protein Refseq : NP_001082
MIM : 104610
UniProt ID : P19801
Chromosome Location : 7q36.1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (16)

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How should the dose of AOC1 be determined? 09/04/2022

The dosage should be determined based on a combination of factors such as the patient's age, physical condition and severity of the condition.

Can AOC1 be taken orally? 08/25/2022

No oral formulation has been developed and can only be administered by injection or intravenous drip.

What are the adverse reactions of AOC1 ? 07/28/2022

Mild adverse reactions such as drowsiness, headache, and nausea may occur, and in severe cases, allergic reactions and elevated blood pressure may occur.

What are the preservation conditions of AOC1 ? 07/04/2022

The storage temperature is usually -20°C to avoid repeated freezing and thawing and exposure to light.

How to evaluate the efficacy of AOC1 ? 03/07/2022

Efficacy evaluation needs to be carried out according to the pathophysiological characteristics and treatment criteria of different diseases.

How can AOC1 be further promoted and popularized? 01/17/2022

Large-scale clinical research and economic evaluation are needed, as well as publicity and science popularization.

What is the action mechanism of AOC1? 12/20/2021

AOC1 can promote the protection and repair of cardiovascular system and nervous system by regulating the level of angiotensin (Ang II), and inhibit tumor growth and deterioration.

How reproducible is AOC1 ? 10/16/2021

Reproducibility needs to be enhanced through multi-center clinical trials and product quality monitoring.

Does the use of AOC1 with other drugs affect the effect? 02/07/2021

The possibility of interaction needs to be assessed on a patient-specific basis.

What is the bioavailability of AOC1 ? 07/10/2020

It needs to be evaluated according to different formulations and modes of administration.

How does AOC1 get approved through clinical trials? 04/18/2020

It needs to be proven safe and effective in tightly controlled clinical trials and then submitted to drug regulators.

Can AOC1 be used for long-term therapy? 02/28/2020

Long-term treatment options need to be evaluated according to the characteristics and treatment criteria of different diseases.

Can AOC1 replace existing drugs? 01/21/2020

Substitutability and advantages of different diseases need to be evaluated according to their characteristics and treatment criteria.

What are the limitations of AOC1 in clinical application? 10/27/2019

No large-scale clinical studies have been conducted, and further confirmation of its potential safety and efficacy is needed.

In what diseases might AOC1 play a role? 08/25/2019

Recombinant AOC1 may play a role in the treatment of cancer, cardiovascular disease and neurodegenerative diseases.

What is the production process of AOC1 ? 06/01/2019

The production process usually includes gene cloning, transfection, expression, purification and other steps.

Customer Reviews (3)

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Reviews
07/10/2021

    AOC1 still maintains its original stability after repeated freezing and thawing, which is very conducive to our experiment.

    09/20/2019

      High purity can reduce the error in the experiment and improve the repeatability of the experiment.

      07/20/2019

        The resolution of AOC1 in Western blot is high, which can distinguish similar protein molecular weights.

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