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Active Recombinant Rat Il6st, Fc Chimera

Cat.No. : Il6st-539R
Product Overview : Recombinant Rat Il6st (Accession # EDM10349) was produced in Mouse myeloma cell line, NS0-derived.
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Source : Mammalian cells
Species : Rat
Tag : Fc Chimera
Predicted N Terminal : No results obtained: Gln23 predicted & Tyr30
Form : Lyophilized from a 0.2 µm filtered solution in PBS.
Bio-activity : Measured by its ability to inhibit the IL-6 R alpha enhancement of IL-6 activity on M1 mouse myeloid leukemia cells. Saito, T. et al. (1991) J. Immunol. 147:168.The ED50 for this effect is typically 5 - 30 ng/mL in the presence of 10 ng/mL recombinant human (rh) IL-6 R alpha and 20 ng/mL of rhIL-6.
Molecular Mass : Recombinant Rat Il6st, Fc Chimera has a calculated MW of 94 kDa (monomer). In SDS-PAGE migrates as 105-130 kDa, reducing conditions.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name : Il6st interleukin 6 signal transducer [ Rattus norvegicus ]
Official Symbol : Il6st
Synonyms : IL6ST; interleukin 6 signal transducer; interleukin-6 receptor subunit beta; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; interleukin-6 signal transducer; oncostatin-M receptor subunit alpha; Gp130; Ac1055; Il-6rb;
Gene ID : 25205
mRNA Refseq : NM_001008725
Protein Refseq : NP_001008725
MIM :

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to detect IL6ST activity? 04/26/2022

The activity of IL6ST is usually detected by cell differentiation and proliferation assay.

In what diseases does IL6ST have applications? 04/20/2021

IL6ST may be used in the future to treat pulmonary fibrosis, chronic pulmonary obstruction, rheumatoid arthritis, and other chronic kidney diseases.

Are there any effects of IL6ST on cell differentiation? 04/15/2021

IL6ST is involved in various inflammatory responses and cell differentiation processes.

What are the physical and chemical properties of IL6ST? 02/03/2021

The physical and chemical properties of IL6ST include molecular weight, voltammetry potential, structure and stability.

Why research IL6ST? 02/09/2019

The study of IL6ST helps us to better understand the disease mechanism involved in IL6ST, and provides new ideas and means for disease treatment.

What is the preparation method of IL6ST? 01/27/2019

The IL6ST is usually prepared by transforming E. coli into an expression vector and making it express the IL6ST protein.

Customer Reviews (3)

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Reviews
02/28/2022

    IL6ST proteins can be functionally enhanced or altered by protein modification techniques.

    08/04/2020

      As an immunotherapy drug, it has good effect and high safety.

      09/06/2019

        Has a good inhibitory effect on cell proliferation and survival.

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