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Active Recombinant Human INSR, His-tagged

Cat.No. : INSR-661H
Product Overview : Recombinant Human INSR (Accession # NP_001073285) His28-Arg750 ( alpha subunit) & Ser751-Lys944, fused with a C-terminal 10-His tag ( beta subunit), was produced in Mouse myeloma cell line, NS0-derived.
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  • Gene Information
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Source : Mammalian cells
Species : Human
Tag : His
Predicted N Terminal : His28 ( alpha subunit) & Ser751( beta subunit)
Form : Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
Bio-activity : Measured by its binding ability in a functional ELISA.When 15 ng/mL of biotinylated recombinant human Insulin is added to serially diluted Recombinant Human Insulin R/CD220, the concentration of Recombinant Human Insulin R/CD220 that produces 50% of the optimal binding response is typically 0.03-0.15 µg/mL.
Molecular Mass : Recombinant Human INSR, His-tagged has a calculated MW of 82.9 kDa ( alpha subunit), 22.9 kDa ( beta subunit). In SDS-PAGE migrates as 122-135 kDa and 33-43 kDa, reducing conditions.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Reconstitution : Reconstitute at 100 µg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Gene Name : INSR insulin receptor [ Homo sapiens ]
Official Symbol : INSR
Synonyms : INSR; insulin receptor; CD220; IR; HHF5;
Gene ID : 3643
mRNA Refseq : NM_000208
Protein Refseq : NP_000199
MIM : 147670
UniProt ID : P06213
Chromosome Location : 19p13.3-p13.2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What impact does malfunction or dysregulation of the insulin receptor (INSR) have on metabolic health? 10/31/2020

Malfunction or dysregulation of the insulin receptor (INSR) can lead to disturbances in metabolic health, contributing to conditions like diabetes.

How does the insulin receptor (INSR) function in regulating glucose metabolism in cells? 04/08/2020

INSR regulates glucose metabolism by facilitating the cellular uptake of glucose in response to insulin.

What are the key tissues or cell types where the insulin receptor (INSR) is prominently expressed? 08/29/2019

The insulin receptor (INSR) is prominently expressed in tissues such as the liver, muscle, and adipose tissue.

Are there known genetic variations or mutations in the insulin receptor (INSR) associated with metabolic disorders or insulin resistance? 02/27/2019

Genetic variations or mutations in the insulin receptor (INSR) are associated with certain metabolic disorders and insulin resistance.

In the context of diabetes, what role does the insulin receptor (INSR) play in the development of insulin resistance? 06/16/2018

In diabetes, the insulin receptor (INSR) contributes to the development of insulin resistance, impairing its normal signaling functions.

What is the primary role of the insulin receptor (INSR) protein in cellular processes? 04/29/2017

The insulin receptor (INSR) protein plays a crucial role in cellular processes, particularly in mediating the effects of insulin.

How does the insulin receptor (INSR) activate downstream signaling pathways in response to insulin binding? 09/14/2016

Upon insulin binding, the insulin receptor (INSR) activates downstream signaling pathways, including the PI3K-AKT pathway.

Customer Reviews (3)

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Reviews
02/25/2020

    The compatibility with a range of lab equipment streamlined experimental procedures, saving both time and effort.

    04/26/2016

      The product's support in the form of educational resources positively impacted the learning curve for our researchers.

      04/18/2016

        The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.

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