Active Recombinant Human INSR, His-tagged
Cat.No. : | INSR-661H |
Product Overview : | Recombinant Human INSR (Accession # NP_001073285) His28-Arg750 ( alpha subunit) & Ser751-Lys944, fused with a C-terminal 10-His tag ( beta subunit), was produced in Mouse myeloma cell line, NS0-derived. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | His28 ( alpha subunit) & Ser751( beta subunit) |
Form : | Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein. |
Bio-activity : | Measured by its binding ability in a functional ELISA.When 15 ng/mL of biotinylated recombinant human Insulin is added to serially diluted Recombinant Human Insulin R/CD220, the concentration of Recombinant Human Insulin R/CD220 that produces 50% of the optimal binding response is typically 0.03-0.15 µg/mL. |
Molecular Mass : | Recombinant Human INSR, His-tagged has a calculated MW of 82.9 kDa ( alpha subunit), 22.9 kDa ( beta subunit). In SDS-PAGE migrates as 122-135 kDa and 33-43 kDa, reducing conditions. |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Reconstitution : | Reconstitute at 100 µg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
Gene Name : | INSR insulin receptor [ Homo sapiens ] |
Official Symbol : | INSR |
Synonyms : | INSR; insulin receptor; CD220; IR; HHF5; |
Gene ID : | 3643 |
mRNA Refseq : | NM_000208 |
Protein Refseq : | NP_000199 |
MIM : | 147670 |
UniProt ID : | P06213 |
Chromosome Location : | 19p13.3-p13.2 |
Products Types
◆ Recombinant Protein | ||
INSR-3163H | Recombinant Human INSR Protein, His (Fc)-Avi-tagged | +Inquiry |
INSR-1605C | Recombinant Crab-eating Macaque INSR Protein, Fc-tagged | +Inquiry |
INSR-5093H | Active Recombinant Human INSR Protein, GST-tagged | +Inquiry |
INSR-5092H | Recombinant Human INSR Protein, GST-tagged | +Inquiry |
INSR-1260H | Recombinant Human INSR Protein, His-SUMO-tagged | +Inquiry |
◆ Lysates | ||
INSR-2648HCL | Recombinant Human INSR cell lysate | +Inquiry |
INSR-474HCL | Recombinant Human INSR cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1605 | U2OS INSR Bioassay Kit | +Inquiry |
Kit-1607 | INSR Internalization Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionMalfunction or dysregulation of the insulin receptor (INSR) can lead to disturbances in metabolic health, contributing to conditions like diabetes.
INSR regulates glucose metabolism by facilitating the cellular uptake of glucose in response to insulin.
The insulin receptor (INSR) is prominently expressed in tissues such as the liver, muscle, and adipose tissue.
Genetic variations or mutations in the insulin receptor (INSR) are associated with certain metabolic disorders and insulin resistance.
In diabetes, the insulin receptor (INSR) contributes to the development of insulin resistance, impairing its normal signaling functions.
The insulin receptor (INSR) protein plays a crucial role in cellular processes, particularly in mediating the effects of insulin.
Upon insulin binding, the insulin receptor (INSR) activates downstream signaling pathways, including the PI3K-AKT pathway.
Customer Reviews (3)
Write a reviewThe compatibility with a range of lab equipment streamlined experimental procedures, saving both time and effort.
The product's support in the form of educational resources positively impacted the learning curve for our researchers.
The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.
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