Active Recombinant Rat Il17a
Cat.No. : | Il17a-680R |
Product Overview : | Recombinant Rat Il17a (Accession # NP_001100367) Ala26-Ser158 was produced in Chinese Hamster Ovary cell line, CHO-derived. |
- Specification
- Gene Information
- Related Products
Source : | CHO cells |
Species : | Rat |
Predicted N Terminal : | Ala26 & Val27 |
Form : | Lyophilized from a 0.2 µm filtered solution in sterile PBS with BSA as a carrier protein. |
Bio-activity : | Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. Yao, Z. et al. (1995) Immunity 3:811.The ED50 for this effect is typically 0.25-1.25 ng/mL |
Molecular Mass : | Recombinant Rat Il17a has a calculated MW of 15 kDa. In SDS-PAGE migrates as 13-22 kDa, reducing conditions. |
Purity : | >95%, by SDS-PAGE with silver staining. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Reconstitution : | Reconstitute at 100 µg/mL in PBS containing at least 0.1% human or bovine serum albumin. |
Gene Name : | Il17a interleukin 17A [ Rattus norvegicus ] |
Official Symbol : | Il17a |
Synonyms : | IL17A; interleukin 17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); Il17; IL-17; CTLA-8; IL-17A; |
Gene ID : | 301289 |
mRNA Refseq : | NM_001106897 |
Protein Refseq : | NP_001100367 |
MIM : |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAnimal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.
Inducing IL17A expression in T cells involves culturing them with specific cytokines.
Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.
Neutralizing antibodies block IL17A's effects in cell cultures or animal models.
Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.
IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.
Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.
Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.
Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.
Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.
Customer Reviews (3)
Write a reviewGood for receptor studies.
Effective in Th17 differentiation.
High bioactivity in various tissue types.
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