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Active Recombinant Rat Il17a

Cat.No. : Il17a-680R
Product Overview : Recombinant Rat Il17a (Accession # NP_001100367) Ala26-Ser158 was produced in Chinese Hamster Ovary cell line, CHO-derived.
  • Specification
  • Gene Information
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Source : CHO cells
Species : Rat
Predicted N Terminal : Ala26 & Val27
Form : Lyophilized from a 0.2 µm filtered solution in sterile PBS with BSA as a carrier protein.
Bio-activity : Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. Yao, Z. et al. (1995) Immunity 3:811.The ED50 for this effect is typically 0.25-1.25 ng/mL
Molecular Mass : Recombinant Rat Il17a has a calculated MW of 15 kDa. In SDS-PAGE migrates as 13-22 kDa, reducing conditions.
Purity : >95%, by SDS-PAGE with silver staining.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Reconstitution : Reconstitute at 100 µg/mL in PBS containing at least 0.1% human or bovine serum albumin.
Gene Name : Il17a interleukin 17A [ Rattus norvegicus ]
Official Symbol : Il17a
Synonyms : IL17A; interleukin 17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); Il17; IL-17; CTLA-8; IL-17A;
Gene ID : 301289
mRNA Refseq : NM_001106897
Protein Refseq : NP_001100367
MIM :

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Could you explain the role of IL17A in autoimmune disease progression using animal models? 05/22/2022

Animal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.

Can you detail the protocols for inducing IL17A expression in T cells in vitro? 01/02/2021

Inducing IL17A expression in T cells involves culturing them with specific cytokines.

What strategies elucidate IL17A's impact on tissue-specific inflammation in human samples? 02/17/2020

Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.

Can you elaborate on the use of neutralizing antibodies in blocking IL17A's effects? 06/12/2019

Neutralizing antibodies block IL17A's effects in cell cultures or animal models.

How does one perform a multiplex cytokine assay to quantify IL17A along with other cytokines? 12/13/2018

Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.

How is the IL17A receptor (IL17RA) signaling pathway activated and studied? 11/23/2018

IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.

What are the methods to investigate the impact of IL17A on epithelial barrier integrity? 08/09/2018

Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.

How is IL17A's contribution to neutrophil recruitment assessed in inflammatory models? 06/25/2018

Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.

What techniques are used to analyze IL17A-producing cell populations within a tissue? 06/22/2018

Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.

What experimental design is employed to understand IL17A's involvement in cancer development? 03/23/2018

Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.

Customer Reviews (3)

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Reviews
12/16/2018

    Good for receptor studies.

    03/05/2018

      Effective in Th17 differentiation.

      03/08/2017

        High bioactivity in various tissue types.

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