Active Recombinant Human CLU, His-tagged
Cat.No. : | CLU-722H |
Product Overview : | Recombinant Human CLU (Accession # NP_001822) Asp23-Arg227 (beta) & Ser228-Glu449 (alpha), fused with a C-terminal 6-His tag, was produced in Mouse myeloma cell line, NS0-derived. |
- Specification
- Gene Information
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Source : | Mammalian cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Ser228 ( alpha chain) & Asp23 ( beta chain) |
Form : | Lyophilized from a 0.2 µm filtered solution in PBS. |
Bio-activity : | Measured by its ability to induce clustering of Caki-2 human clear cell carcinoma epithelial cells. Schwochau, G. et al. (1998) Kidney Int. 53:1647.The ED50 for this effect is approximately 0.3 µg/mL in the presence of 25 ng/mL of Recombinant Rat GDNF. |
Molecular Mass : | Recombinant Human CLU, His-tagged has a calculated MW of 26.7 kDa ( alpha chain) and 24.2 kDa ( beta chain). In SDS-PAGE migrates as 40 kDa and 39 kDa, under reducing conditions. |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Gene Name : | CLU clusterin [ Homo sapiens ] |
Official Symbol : | CLU |
Synonyms : | CLU; clusterin; APOJ, CLI, clusterin (complement lysis inhibitor, SP 40,40, sulfated glycoprotein 2, testosterone repressed prostate message 2, apolipoprotein J); apolipoprotein J; complement lysis inhibitor; KUB1; SGP 2; SP 40; sulfated glycoprotein 2; testosterone repressed prostate message 2; TRPM 2; ku70-binding protein 1; aging-associated protein 4; complement cytolysis inhibitor; complement-associated protein SP-40,40; testosterone-repressed prostate message 2; CLI; AAG4; APOJ; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2; MGC24903; |
Gene ID : | 1191 |
mRNA Refseq : | NM_001831 |
Protein Refseq : | NP_001822 |
MIM : | 185430 |
UniProt ID : | P10909 |
Chromosome Location : | 8p21-p12 |
Products Types
◆ Recombinant Protein | ||
CLU-621H | Recombinant Human CLU Protein, His (Fc)-Avi-tagged | +Inquiry |
CLU-803H | Recombinant Human CLU Protein, His&GST-tagged | +Inquiry |
CLU-3277H | Recombinant Human CLU Protein, MYC/DDK-tagged | +Inquiry |
CLU-746R | Recombinant Rhesus Macaque CLU Protein, His (Fc)-Avi-tagged | +Inquiry |
CLU-1526H | Recombinant Human CLU Protein, GST-tagged | +Inquiry |
◆ Native Protein | ||
CLU-19H | Native Human Clusterin Protein | +Inquiry |
CLU-67H | Native Human Clusterin | +Inquiry |
◆ Lysates | ||
CLU-2198HCL | Recombinant Human CLU cell lysate | +Inquiry |
CLU-2195MCL | Recombinant Mouse CLU cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCLU has anti-inflammatory properties and modulates immune responses. Its involvement in autoimmunity is linked to its ability to regulate immune cell functions and cytokine production.
CLU plays a role in regulating cell survival and apoptosis by interacting with key cellular components, including Bcl-2 family members and caspases, modulating apoptotic pathways.
CLU modulates cell adhesion and migration, contributing to tissue remodeling and repair. Its interactions with extracellular matrix components influence cellular behaviors in wound healing and tissue homeostasis.
CLU is implicated in neurodegenerative disorders, particularly Alzheimer's disease. Its involvement in processes such as amyloid-beta aggregation and clearance influences disease progression.
CLU interacts with lipids, participating in lipid transport and metabolism. Its role in lipoprotein remodeling and cholesterol homeostasis links it to cardiovascular health.
Customer Reviews (3)
Write a reviewImpressed with the quality control. This product is a gem in our lab experiments.
Smooth transactions and swift delivery. Our lab supplies are incomplete without this protein.
Our lab manager introduced us to this product, and we're never going back. Essential for our studies.
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