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Active Recombinant Human CLU, His-tagged

Cat.No. : CLU-722H
Product Overview : Recombinant Human CLU (Accession # NP_001822) Asp23-Arg227 (beta) & Ser228-Glu449 (alpha), fused with a C-terminal 6-His tag, was produced in Mouse myeloma cell line, NS0-derived.
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  • Gene Information
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Source : Mammalian cells
Species : Human
Tag : His
Predicted N Terminal : Ser228 ( alpha chain) & Asp23 ( beta chain)
Form : Lyophilized from a 0.2 µm filtered solution in PBS.
Bio-activity : Measured by its ability to induce clustering of Caki-2 human clear cell carcinoma epithelial cells. Schwochau, G. et al. (1998) Kidney Int. 53:1647.The ED50 for this effect is approximately 0.3 µg/mL in the presence of 25 ng/mL of Recombinant Rat GDNF.
Molecular Mass : Recombinant Human CLU, His-tagged has a calculated MW of 26.7 kDa ( alpha chain) and 24.2 kDa ( beta chain). In SDS-PAGE migrates as 40 kDa and 39 kDa, under reducing conditions.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name : CLU clusterin [ Homo sapiens ]
Official Symbol : CLU
Synonyms : CLU; clusterin; APOJ, CLI, clusterin (complement lysis inhibitor, SP 40,40, sulfated glycoprotein 2, testosterone repressed prostate message 2, apolipoprotein J); apolipoprotein J; complement lysis inhibitor; KUB1; SGP 2; SP 40; sulfated glycoprotein 2; testosterone repressed prostate message 2; TRPM 2; ku70-binding protein 1; aging-associated protein 4; complement cytolysis inhibitor; complement-associated protein SP-40,40; testosterone-repressed prostate message 2; CLI; AAG4; APOJ; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2; MGC24903;
Gene ID : 1191
mRNA Refseq : NM_001831
Protein Refseq : NP_001822
MIM : 185430
UniProt ID : P10909
Chromosome Location : 8p21-p12

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does CLU contribute to the regulation of inflammation, and what role does it play in immune responses and autoimmunity? 05/03/2022

CLU has anti-inflammatory properties and modulates immune responses. Its involvement in autoimmunity is linked to its ability to regulate immune cell functions and cytokine production.

How does CLU contribute to the regulation of cell survival and apoptosis, and what are the molecular mechanisms involved? 03/08/2021

CLU plays a role in regulating cell survival and apoptosis by interacting with key cellular components, including Bcl-2 family members and caspases, modulating apoptotic pathways.

How does CLU influence cell adhesion and migration, and what role does it play in tissue remodeling and repair processes? 01/16/2020

CLU modulates cell adhesion and migration, contributing to tissue remodeling and repair. Its interactions with extracellular matrix components influence cellular behaviors in wound healing and tissue homeostasis.

Can you discuss the association between CLU and neurodegenerative disorders, and how does it impact the pathogenesis of conditions like Alzheimer's disease? 11/16/2019

CLU is implicated in neurodegenerative disorders, particularly Alzheimer's disease. Its involvement in processes such as amyloid-beta aggregation and clearance influences disease progression.

Can you elaborate on the molecular interactions of CLU with lipids and its involvement in lipid transport and metabolism? 07/24/2018

CLU interacts with lipids, participating in lipid transport and metabolism. Its role in lipoprotein remodeling and cholesterol homeostasis links it to cardiovascular health.

Customer Reviews (3)

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Reviews
11/30/2021

    Impressed with the quality control. This product is a gem in our lab experiments.

    01/22/2019

      Smooth transactions and swift delivery. Our lab supplies are incomplete without this protein.

      04/17/2018

        Our lab manager introduced us to this product, and we're never going back. Essential for our studies.

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