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Active Recombinant Human TP53, His-tagged

Cat.No. : TP53-3412H
Product Overview : Recombinant human p53 produced in E.coli is a single, non-glycosylated, polypeptide chain with a 6His tag at the N-terminus. It contains 412 (19+393) amino acids, and having a predicted molecular mass of approximately 45.8kD, but migrates in SDS-PAGE with an apparent molecular mass of 55kD.
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Description : Tumor proteins p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), are encoded by homologous genes in various organisms such as TP53 (humans) and Trp53 (mice). This homolog is crucial in multicellular organisms, where it prevents cancer formation, thus, functions as a tumor suppressor. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.
Source : E. coli
Species : Human
Tag : His
Form : 10mM HEPES-Na (pH7.9), 150mM NaCl and 3mM EDTA
Bio-activity : Tumor suppressor protein p53 is involved in transcription activation, DNA repair, cell cycle arrest and apoptosis. Recombinant human p53 protein is ideal for the studies of transcriptional activation, protein-protein interactions and other related function assays.
AA Sequence : MHHHHHHGRRASVEDVVCCSEEPQS DPSVEPPLSQETFSDLWKLLPENNV LSPLPSQAMDDLMLSPDDIEQWFT EDPGPDEAPRMPEAAPPVAPAPAAP TPAAPAPAPSWPLSSSVPSQKTYQG SYGFRLGFLHSGTAKSVTCTYSPA LNKMFCQLAKTCPVQLWVDSTPPPG TRVRAMAIYKQSQHMTEVVRRCPHH ERCSDSDGLAPPQHLIRVEGNLR VEYLDDRNTFRHSVVVPYEPPEVGS DCTTIHYNYMCNSSCMGGMNRRPIL TIITLEDSSGNLLGRNSFEVRVCA CPGRDRRTEEENLRKKGEPHHELPP GSTKRALPNNTSSSPQPKKKPLDGE YFTLQIRGRERFEMFRELNEALE LKDAQAGKEPGGSRAHSSHLKSKKG QSTSRHKKLMFKTEGPDSD
Purity : ≥90%, as determined by SDS-PAGE
Usage : FOR RESEARCH ONLY
Storage : The protein sample can be stored under sterile conditions at 2- 8 centigrade for one month or at -70 centigrade for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Gene Name : TP53 tumor protein p53 [ Homo sapiens ]
Official Symbol : TP53
Synonyms : P53; BCC7; LFS1; TRP53; cellular tumor antigen p53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; tumor protein 53
Gene ID : 7157
mRNA Refseq : NM_000546
Protein Refseq : NP_000537
MIM : 191170
UniProt ID : P04637
Chromosome Location : 17p13.1
Pathway : AMPK signaling, organism-specific biosystem; Activation of BH3-only proteins, organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem
Function : ATP binding; DNA binding; MDM2/MDM4 family protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can TP53 status be used for cancer risk assessment and screening in individuals with a family history of cancer? 07/21/2022

Yes, identifying TP53 mutations in families with a history of early-onset cancers can help identify individuals at high risk for cancer and guide screening and prevention strategies.

What are the challenges in developing targeted therapies for TP53-mutated cancers? 05/21/2019

TP53 mutations are highly diverse, making it challenging to develop a one-size-fits-all therapy. Additionally, the p53 pathway is complex, and disrupting it can have unintended consequences.

Can TP53 status influence eligibility for certain clinical trials? 12/06/2018

Yes, TP53 mutation status can be a criterion for eligibility in specific clinical trials, especially those testing experimental treatments that may target the p53 pathway.

How might TP53 status affect decisions regarding surgery, chemotherapy, and radiation therapy? 08/13/2017

TP53 status can influence treatment decisions. For example, patients with TP53 mutations may require more aggressive treatment approaches or different chemotherapy regimens.

Are there targeted therapies specifically designed for TP53-mutated cancers? 06/05/2016

Currently, there are no specific targeted therapies approved solely for TP53-mutated cancers. However, research is ongoing to develop drugs that target the altered p53 pathway.

Customer Reviews (3)

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Reviews
02/26/2023

    By actively engaging with researchers and understanding their needs, manufacturers can contribute significantly to the success and impact of research involving the TP53 protein.

    11/05/2020

      This flexibility allows for tailored approaches and provides researchers with more options to study specific aspects of TP53 biology or its interactions with other molecules.

      07/24/2017

        Manufacturers can provide comprehensive product information, including data on the functionality, stability, and handling of TP53 protein.

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