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Active Recombinant Human TNF

Cat.No. : TNF-1452H
Product Overview : Recombinant human TNF-α produced in E.coli is a single, non-glycosylated, polypeptide chain containing 157 amino acids, two pairs of disulfide bonds and having a molecular mass of approximately 17.4kDa.
  • Specification
  • Gene Information
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Description : Human TNF-α is a 17.4kD factor produced by macrophages, monocytes, neutrophils, CD4+ T cells and NK cells. A 26kD form of TNF-α is expressed as a membrane bound molecule. TNF-α is cytolytic and plays an important role in immune regulation. Dimers and trimers of TNF-α have been observed.
Source : E. coli
Species : Human
Form : Lyophilized from a 0.2μm filtered solution in 40mM Tris-HCl, 40mM NaCl, containing 0.1% human serum albumin, pH8.0.
Bio-activity : Specific Activity shall be not less than 2 x10^7 IU/mg.
Endotoxin : ≤1EU/μg, determined by the LAL method.
Purity : ≥95%, as determined by SDS-PAGE and HPLC method.
Usage : FOR RESEARCH ONLY
Storage : Lyophilized samples are stable for greater than six months from date of receipt at -20 centigrade to -70 centigrade. The reconstituted samples can be stored under sterile conditions at 2-8 centigrade for one month or at -20 centigrade to -70 centigrade for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended to reconstitute the lyophilized rHuTNF-α in sterile ddH2O not less than 100μg/ml, containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution.
Gene Name : TNF tumor necrosis factor [ Homo sapiens ]
Official Symbol : TNF
Synonyms : DIF; TNFA; TNFSF2; TNF-alpha; tumor necrosis factor; APC1 protein; TNF, macrophage-derived; TNF, monocyte-derived; TNF-a; cachectin; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha
Gene ID : 7124
mRNA Refseq : NM_000594
Protein Refseq : NP_000585
MIM : 191160
UniProt ID : P01375
Chromosome Location : 6p21.3
Pathway : Adipocytokine signaling pathway, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; Alzheimers Disease, organism-specific biosystem
Function : cytokine activity; identical protein binding; protease binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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