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Active Recombinant Mouse Tgfbr3 Protein, His-tagged

Cat.No. : Tgfbr3-658M
Product Overview : Recombinant Mouse Tgfbr3 (Accession # NP_035708) Gly23-Thr785, fused with a C-terminal 6-His tag, was produced in Mouse myeloma cell line, NS0-derived.
  • Specification
  • Gene Information
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Source : Mammalian cells
Species : Mouse
Tag : His
Predicted N Terminal : Gly23
Form : Lyophilized from a 0.2 µm filtered solution in PBS.
Bio-activity : Measured by its ability to inhibit TGF-beta 2 activity on HT-2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389.The ED50 for this effect is typically 8 - 40 ng/mL in the presence of 1 ng/mL of rhTGF-beta 2.
Molecular Mass : Recombinant Mouse Tgfbr3, His-tagged has a calculated MW of 85.6 kDa. In SDS-PAGE migrates as 105-115 kDa, reducing conditions.
Protein length : Gly23-Thr785
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name : Tgfbr3 transforming growth factor, beta receptor III [ Mus musculus ]
Official Symbol : Tgfbr3
Synonyms : TGFBR3; transforming growth factor, beta receptor III; transforming growth factor beta receptor type 3; TGFR-3; betaglycan; TGF-beta receptor type 3; TGF-beta receptor type III; TBRIII; AU015626; AW215636; 1110036H20Rik;
Gene ID : 21814
mRNA Refseq : NM_011578
Protein Refseq : NP_035708
MIM :

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the implications of TGFBR3 mutations in the context of hereditary connective tissue disorders? 03/05/2022

TGFBR3 mutations are associated with hereditary connective tissue disorders, impacting extracellular matrix homeostasis and contributing to conditions like Loeys-Dietz syndrome.

How does TGFBR3 influence embryonic development, and what are the consequences of its dysregulation during development? 04/26/2021

TGFBR3 plays a role in embryonic development, and dysregulation may lead to developmental abnormalities due to disrupted TGF-beta signaling.

Can you explain the role of TGFBR3 in mediating interactions between cells and extracellular matrix components? 07/15/2019

TGFBR3 facilitates cell-ECM interactions by modulating TGF-beta signaling, influencing processes like cell adhesion and migration.

How does TGFBR3 contribute to the modulation of TGF-beta signaling pathways? 05/24/2018

TGFBR3 acts as a co-receptor, enhancing the binding of TGF-beta ligands to TGF-beta receptors, and modulates downstream signaling events.

What are the functional consequences of TGFBR3 mutations in the context of cardiovascular diseases? 02/11/2018

TGFBR3 mutations are implicated in cardiovascular diseases, affecting TGF-beta-mediated processes in vascular smooth muscle cells and cardiac tissues.

Customer Reviews (3)

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Reviews
05/10/2022

    Great product !

    02/18/2020

      Seamless delivery process—ordered, received, and ready for experiments.

      08/31/2018

        Timely delivery is key, and this product arrived on schedule.

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