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Active Recombinant Mouse C2 Protein, His-tagged

Cat.No. : C2-1012M
Product Overview : Recombinant Mouse C2 (Accession # O70350) Met1-Leu760, fused with a C-terminal 6-His tag, was produced in Mouse myeloma cell line, NS0-derived.
  • Specification
  • Gene Information
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Source : Mammalian cells
Species : Mouse
Tag : His
Predicted N Terminal : Leu20 & Lys251
Form : Supplied as a 0.2 µm filtered solution in Sodium Acetate and NaCl.
Bio-activity : Measured by its ability to cleave a colorimetric peptide substrate, N-carbobenzyloxy-Gly-Arg-ThioBenzyl ester (Z-GR-SBzl), in the presence of 5,5"Dithio-bis (2-nitrobenzoic acid) (DTNB). Edwards, K.M. et al. (1999) J. Biol. Chem. 274:30468.The specific activity is >200 pmol/min/µg, as measured under the described conditions.
Molecular Mass : Recombinant Mouse C2, His-tagged has a calculated MW of 58 kDa and 84 kDa. In SDS-PAGE migrates as 66-75 kDa & 90-110 kDa, reducing conditions.
Protein length : Met1-Leu760
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Reconstitution : Reconstitute at 50 µg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Gene Name : C2 complement component 2 (within H-2S) [ Mus musculus ]
Official Symbol : C2
Synonyms : C2; complement component 2 (within H-2S); complement C2; C3/C5 convertase; complement factor C2; MHC complement component C2; classical-complement pathway C3/C5 convertase;
Gene ID : 12263
mRNA Refseq : NM_013484
Protein Refseq : NP_038512
MIM :

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can C2 protein be a target for drug development in autoimmune disorders? 01/13/2023

Yes, drugs targeting C2 or the complement system are being explored as potential treatments for autoimmune diseases to regulate the immune response.

Can C2 protein be used as a diagnostic marker for immune system disorders? 05/18/2021

Yes, the absence or dysfunction of C2 protein can be indicative of immune system disorders, and its levels can be assessed for diagnostic purposes.

Can C2 protein be used in vaccine development? 06/21/2019

Understanding C2's role in immune activation may contribute to vaccine design, potentially enhancing the effectiveness of vaccines by targeting the complement system.

How does C2 protein contribute to autoimmune diseases? 11/26/2018

Abnormal activation of the complement system, including C2, is associated with some autoimmune diseases where the immune system mistakenly attacks the body's own cells.

Are there genetic factors influencing C2 protein levels and function? 05/27/2017

Yes, genetic variations can affect C2 protein expression and function, leading to variations in immune response among individuals.

Customer Reviews (3)

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Reviews
02/02/2023

    The C2 protein comes highly recommended for its excellent performance in various research applications.

    12/25/2020

      It has demonstrated exceptional effectiveness in WB experiments, showcasing its reliability and precision in detecting and quantifying specific targets.

      05/08/2019

        Researchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.

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