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Active Recombinant Mouse Lrp6 Protein, His-tagged

Cat.No. : Lrp6-1051M
Product Overview : Recombinant Mouse Lrp6 (Accession # O88572) Ala20-Pro1368, fused with a C-terminal 6-His tag, was produced in Mouse myeloma cell line, NS0-derived.
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  • Gene Information
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Source : Mammalian cells
Species : Mouse
Tag : His
Predicted N Terminal : Ala20
Form : Lyophilized from a 0.2 µm filtered solution in PBS.
Bio-activity : Measured by its binding ability in a functional ELISA.rmLRP-6 binds rhDkk-1, biotin with an apparent KD < 15 nM.Biotinylated rmWnt-3a immobilized on a streptavidin-coated plate at 1 µg/mL can bind rmLRP-6 with a linear range of 0.2 - 10 µg/mL.
Molecular Mass : Recombinant Mouse Lrp6, His-tagged has a calculated MW of 152.6 kDa. In SDS-PAGE migrates as 170 kDa, reducing conditions.
Protein length : Ala20-Pro1368
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name : Lrp6 low density lipoprotein receptor-related protein 6 [ Mus musculus ]
Official Symbol : Lrp6
Synonyms : LRP6; low density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6; LRP-6; crooked; low density lipoprotein-related protein 6; Cd; Gw; C030016K15Rik;
Gene ID : 16974
mRNA Refseq : NM_008514
Protein Refseq : NP_032540
MIM :

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does LRP6 interact with Wnt signaling pathways, and what is its role in modulating Wnt signaling? 02/13/2022

LRP6 interacts with Wnt signaling pathways by forming a complex with Frizzled receptors, initiating Wnt pathway activation.

In which cellular compartments is LRP6 predominantly localized? 01/12/2021

LRP6 is predominantly localized on the cell membrane, where it acts as a co-receptor for Wnt ligands.

Are there specific Wnt ligands or co-receptors that LRP6 interacts with, influencing Wnt pathway activation? 11/18/2019

Specific Wnt ligands or co-receptors that LRP6 interacts with include Wnt-1 and Wnt-3a, influencing Wnt pathway activation.

What diseases or conditions are associated with dysregulation or abnormal expression of LRP6? 04/25/2018

Dysregulation or abnormal expression of LRP6 is associated with conditions such as cancer and osteoporosis.

How does LRP6 contribute to the regulation of cell proliferation, differentiation, or tissue development? 05/28/2017

LRP6 contributes to the regulation of cell proliferation, differentiation, and tissue development by modulating Wnt signaling.

Are there therapeutic implications or potential targets related to LRP6 in diseases involving Wnt signaling? 08/19/2016

There are potential therapeutic implications related to LRP6 in diseases involving Wnt signaling, making it a target for drug development.

What is the primary function of Low-density lipoprotein receptor-related protein 6 (LRP6) in cellular processes and signaling? 03/31/2016

Low-density lipoprotein receptor-related protein 6 (LRP6) functions in cellular processes, primarily playing a role in Wnt signaling.

Customer Reviews (3)

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Reviews
04/07/2021

    We appreciated the product's role in supporting open-access initiatives, promoting accessibility to scientific knowledge.

    09/11/2020

      We appreciated the product's recognition in peer-reviewed journals, further establishing its importance in our field.

      01/17/2018

        The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.

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