Active Recombinant Mouse Lrp6 Protein, His-tagged
Cat.No. : | Lrp6-1051M |
Product Overview : | Recombinant Mouse Lrp6 (Accession # O88572) Ala20-Pro1368, fused with a C-terminal 6-His tag, was produced in Mouse myeloma cell line, NS0-derived. |
- Specification
- Gene Information
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Source : | Mammalian cells |
Species : | Mouse |
Tag : | His |
Predicted N Terminal : | Ala20 |
Form : | Lyophilized from a 0.2 µm filtered solution in PBS. |
Bio-activity : | Measured by its binding ability in a functional ELISA.rmLRP-6 binds rhDkk-1, biotin with an apparent KD < 15 nM.Biotinylated rmWnt-3a immobilized on a streptavidin-coated plate at 1 µg/mL can bind rmLRP-6 with a linear range of 0.2 - 10 µg/mL. |
Molecular Mass : | Recombinant Mouse Lrp6, His-tagged has a calculated MW of 152.6 kDa. In SDS-PAGE migrates as 170 kDa, reducing conditions. |
Protein length : | Ala20-Pro1368 |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Gene Name : | Lrp6 low density lipoprotein receptor-related protein 6 [ Mus musculus ] |
Official Symbol : | Lrp6 |
Synonyms : | LRP6; low density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6; LRP-6; crooked; low density lipoprotein-related protein 6; Cd; Gw; C030016K15Rik; |
Gene ID : | 16974 |
mRNA Refseq : | NM_008514 |
Protein Refseq : | NP_032540 |
MIM : |
Products Types
◆ Recombinant Protein | ||
Lrp6-5166M | Recombinant Mouse Lrp6 Protein, His (Fc)-Avi-tagged | +Inquiry |
LRP6-122H | Recombinant Human LRP6 Protein, His (Fc)-Avi-tagged | +Inquiry |
Lrp6-1338M | Recombinant Mouse Lrp6 Protein, MYC/DDK-tagged | +Inquiry |
LRP6-7875HB | Recombinant Human LRP6 Protein, N-His tagged, Avi-biotinylated | +Inquiry |
LRP6-2372R | Recombinant Rhesus Macaque LRP6 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
LRP6-4654HCL | Recombinant Human LRP6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionLRP6 interacts with Wnt signaling pathways by forming a complex with Frizzled receptors, initiating Wnt pathway activation.
LRP6 is predominantly localized on the cell membrane, where it acts as a co-receptor for Wnt ligands.
Specific Wnt ligands or co-receptors that LRP6 interacts with include Wnt-1 and Wnt-3a, influencing Wnt pathway activation.
Dysregulation or abnormal expression of LRP6 is associated with conditions such as cancer and osteoporosis.
LRP6 contributes to the regulation of cell proliferation, differentiation, and tissue development by modulating Wnt signaling.
There are potential therapeutic implications related to LRP6 in diseases involving Wnt signaling, making it a target for drug development.
Low-density lipoprotein receptor-related protein 6 (LRP6) functions in cellular processes, primarily playing a role in Wnt signaling.
Customer Reviews (3)
Write a reviewWe appreciated the product's role in supporting open-access initiatives, promoting accessibility to scientific knowledge.
We appreciated the product's recognition in peer-reviewed journals, further establishing its importance in our field.
The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.
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