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Recombinant Human TNFSF15 protein

Cat.No. : TNFSF15-1071H
Product Overview : Recombinant Human TNFSF15 protein was expressed in Escherichia coli.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene.
Source : E.coli
Species : Human
Form : Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4, with 0.02% Tween-20.
Bio-activity : Fully biologically active when compared to standard. The ED50 as determined by its ability to induce apoptosis using human TF-1 cells is less than 20 ng/ml, corresponding to a specific activity of > 5.0 × 10⁴ IU/mg.
Molecular Mass : Approximately 20.5 kDa, a single non-glycosylated polypeptide chain containing 180 amino acids.
Protein length : 180
AA Sequence : LKGQEFAPSHQQVYAPLRADGDKPR AHLTVVRQTPTQHFKNQFPALHWEH ELGLAFTKNRMNYTNKFLLIPESGD YFIYSQVTFRGMTSECSEIRQAGRP NKPDSITVVITKVTDSYPEPTQLLM GTKSVCEVGSNWFQPIYLGAMFSLQ EGDKLMVNVSDISLVDYTKEDKTFF GAFLL
Endotoxin : Less than 0.1 EU/µg of rHuTL-1A/TNFSF15 as determined by LAL method.
Purity : >97% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : TNFSF15
Official Symbol : TNFSF15
Synonyms : TNFSF15; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand superfamily member 15; MGC129934; MGC129935; TL1; TL1A; TNF ligand related molecule 1; TNF superfamily ligand TL1A; vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor 192A; VEGI; VEGI192A; TNF ligand-related molecule 1; vascular endothelial growth inhibitor-192A;
Gene ID : 9966
mRNA Refseq : NM_001204344
Protein Refseq : NP_001191273
MIM : 604052
UniProt ID : O95150

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does TNFSF15 interact with other components of the immune system? 11/09/2020

TNFSF15 interacts with receptors on immune cells, influencing their activity and contributing to the overall regulation of immune responses.

Are there any current clinical trials targeting TNFSF15 for autoimmune disease treatments? 07/31/2017

Several clinical trials are underway to evaluate the efficacy and safety of therapies targeting TNFSF15 in autoimmune diseases.

Are there any diagnostic implications of TNFSF15 in autoimmune disorders? 01/07/2017

TNFSF15 levels may serve as a biomarker for certain autoimmune conditions, aiding in the diagnosis and monitoring of disease progression.

Can TNFSF15 be a potential target for novel drug development in autoimmune diseases? 12/06/2016

TNFSF15 is considered a promising target for drug development, and ongoing research aims to identify compounds that modulate its activity effectively.

How does TNFSF15 contribute to the pathogenesis of inflammatory bowel disease (IBD)? 05/24/2016

In IBD, TNFSF15 is believed to be involved in the inflammation process, contributing to the chronic nature of the disease.

Customer Reviews (3)

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Reviews
03/21/2022

    They keep up with the latest research findings and continually refine their product based on customer feedback and emerging scientific trends.

    05/01/2021

      Their prompt assistance and prompt response can swiftly resolve any challenges, enabling smooth experimentation and maintaining the integrity of the results.

      10/01/2017

        Their knowledgeable support team is well-equipped to address specific inquiries, suggest experimental protocols, and provide guidance throughout the entire research process.

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