Recombinant Human TNFSF15 protein
Cat.No. : | TNFSF15-1071H |
Product Overview : | Recombinant Human TNFSF15 protein was expressed in Escherichia coli. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. |
Source : | E.coli |
Species : | Human |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4, with 0.02% Tween-20. |
Bio-activity : | Fully biologically active when compared to standard. The ED50 as determined by its ability to induce apoptosis using human TF-1 cells is less than 20 ng/ml, corresponding to a specific activity of > 5.0 × 10⁴ IU/mg. |
Molecular Mass : | Approximately 20.5 kDa, a single non-glycosylated polypeptide chain containing 180 amino acids. |
Protein length : | 180 |
AA Sequence : | LKGQEFAPSHQQVYAPLRADGDKPR AHLTVVRQTPTQHFKNQFPALHWEH ELGLAFTKNRMNYTNKFLLIPESGD YFIYSQVTFRGMTSECSEIRQAGRP NKPDSITVVITKVTDSYPEPTQLLM GTKSVCEVGSNWFQPIYLGAMFSLQ EGDKLMVNVSDISLVDYTKEDKTFF GAFLL |
Endotoxin : | Less than 0.1 EU/µg of rHuTL-1A/TNFSF15 as determined by LAL method. |
Purity : | >97% by SDS-PAGE and HPLC analysis. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | TNFSF15 |
Official Symbol : | TNFSF15 |
Synonyms : | TNFSF15; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand superfamily member 15; MGC129934; MGC129935; TL1; TL1A; TNF ligand related molecule 1; TNF superfamily ligand TL1A; vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor 192A; VEGI; VEGI192A; TNF ligand-related molecule 1; vascular endothelial growth inhibitor-192A; |
Gene ID : | 9966 |
mRNA Refseq : | NM_001204344 |
Protein Refseq : | NP_001191273 |
MIM : | 604052 |
UniProt ID : | O95150 |
Products Types
◆ Recombinant Protein | ||
TNFSF15-5860R | Recombinant Rat TNFSF15 Protein, His (Fc)-Avi-tagged | +Inquiry |
TNFSF15-4688R | Recombinant Rhesus Macaque TNFSF15 Protein, His (Fc)-Avi-tagged | +Inquiry |
TNFSF15-556H | Recombinant Human TNFSF15 Protein, Fc-tagged | +Inquiry |
TNFSF15-150H | Recombinant Human TNFSF15 Trimer protein, N-His-Flag-tagged | +Inquiry |
TNFSF15-326H | Active Recombinant Human TNFSF15 Protein (Gln58-Leu251), C-His tagged, Animal-free, Carrier-free | +Inquiry |
◆ Lysates | ||
TNFSF15-1386RCL | Recombinant Rat TNFSF15 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTNFSF15 interacts with receptors on immune cells, influencing their activity and contributing to the overall regulation of immune responses.
Several clinical trials are underway to evaluate the efficacy and safety of therapies targeting TNFSF15 in autoimmune diseases.
TNFSF15 levels may serve as a biomarker for certain autoimmune conditions, aiding in the diagnosis and monitoring of disease progression.
TNFSF15 is considered a promising target for drug development, and ongoing research aims to identify compounds that modulate its activity effectively.
In IBD, TNFSF15 is believed to be involved in the inflammation process, contributing to the chronic nature of the disease.
Customer Reviews (3)
Write a reviewThey keep up with the latest research findings and continually refine their product based on customer feedback and emerging scientific trends.
Their prompt assistance and prompt response can swiftly resolve any challenges, enabling smooth experimentation and maintaining the integrity of the results.
Their knowledgeable support team is well-equipped to address specific inquiries, suggest experimental protocols, and provide guidance throughout the entire research process.
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