Active Recombinant Human ALDH1A1 protein, His-tagged
Cat.No. : | ALDH1A1-1100H |
Product Overview : | Recombinant Human ALDH1A1(Ser2-Ser501) fused with an N-terminal Met and 6-His tag was expressed in E. coli. |
- Specification
- Gene Information
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Description : | Aldehyde dehydrogenases (ALDHs) are NAD(P)+-dependent enzymes that detoxify aldehydes by oxidizing them to carboxylic acids. Nineteen ALDHs are present in humans, expressed in a variety of organelles and having different substrate preferences. ALDH1A1 is a cytosolic enzyme that preferentially oxidizes retinaldehyde to retinoic acid. ALDH1A1 is expressed in the epithelium of many organs, including brain, liver, testis, eye lens and cornea. ALDH1A1 is highly expressed in brain dopaminergic neurons, where it produces the retinoic acid required for their differentiation and development. The retinoic acid produced by ALDH1A1 is also important for the differentiation of hematopoietic stem cells. ALDH1A1 is a major enzyme in the oxidation of acetaldehyde, a toxic metabolite of ethanol. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Ser2 |
Form : | Supplied as a 0.2 μm filtered solution in Tris, NaCl, Glycerol and DTT. |
Bio-activity : | Measured by its ability to produce NADH during the oxidation of propionaldehyde. The specific activity is >150 pmol/min/μg. |
Molecular Mass : | Predicted Molecular Mass: 56 kDa SDS-PAGE: 57 kDa, reducing conditions |
Endotoxin : | <1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 centigrade as supplied. 3 months, -70 centigrade under sterile conditions after opening. |
Gene Name : | ALDH1A1 aldehyde dehydrogenase 1 family, member A1 [ Homo sapiens ] |
Official Symbol : | ALDH1A1 |
Synonyms : | ALDH1A1; aldehyde dehydrogenase 1 family, member A1; ALDH1, PUMB1; retinal dehydrogenase 1; RALDH1; retinaldehyde dehydrogenase 1; ALHDII; RALDH 1; ALDH class 1; acetaldehyde dehydrogenase 1; aldehyde dehydrogenase 1, soluble; aldehyde dehydrogenase, liver cytosolic; ALDC; ALDH1; PUMB1; ALDH11; ALDH-E1; MGC2318; |
Gene ID : | 216 |
mRNA Refseq : | NM_000689 |
Protein Refseq : | NP_000680 |
MIM : | 100640 |
UniProt ID : | P00352 |
Chromosome Location : | 9q21.13 |
Pathway : | Biological oxidations, organism-specific biosystem; Ethanol oxidation, organism-specific biosystem; Fatty Acid Omega Oxidation, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Phase 1 - Functionalization of compounds, organism-specific biosystem; Retinol metabolism, organism-specific biosystem; |
Function : | Ras GTPase activator activity; aldehyde dehydrogenase (NAD) activity; androgen binding; oxidoreductase activity; retinal dehydrogenase activity; |
Products Types
◆ Recombinant Protein | ||
ALDH1A1-111H | Active Recombinant Human ALDH1A1 Protein | +Inquiry |
ALDH1A1-0341H | Recombinant Human ALDH1A1 Protein (M1-S501), Tag Free | +Inquiry |
ALDH1A1-115H | Recombinant Human ALDH1A1 Protein, His-tagged | +Inquiry |
ALDH1A1-0342H | Recombinant Human ALDH1A1 Protein (M1-S501), His tagged | +Inquiry |
ALDH1A1-270R | Recombinant Rat ALDH1A1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ALDH1A1-8922HCL | Recombinant Human ALDH1A1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionALDH1A1 contributes to cellular detoxification by metabolizing endogenous and exogenous aldehydes, reducing their potential cytotoxic effects.
ALDH1A1's catalytic activity depends on its conserved structural features. Substrate binding involves the aldehyde-binding pocket, and cofactor interaction occurs through the binding of NAD+.
ALDH1A1 contributes to retinoid homeostasis by regulating the levels of active retinoic acid. Dysregulation may lead to diseases associated with vitamin A deficiency or excess.
ALDH1A1 is an aldehyde dehydrogenase enzyme responsible for catalyzing the oxidation of retinaldehyde to retinoic acid, a critical step in the synthesis of retinoids.
ALDH1A1 plays a key role in retinoic acid signaling by generating active retinoic acid. This signaling pathway influences gene expression and cellular differentiation in various tissues.
Customer Reviews (3)
Write a reviewThe attention to detail in quality assurance is commendable. It's a lab favorite for a reason.
Great for assays and experiments. Dependable results make it a lab favorite.
A lab staple! Quality is never compromised, and the shipping is always reliable.
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