Active Recombinant Human FGFR4, Fc-tagged, Biotinylated
Cat.No. : | FGFR4-614H |
Product Overview : | The recombinant human FGFR4 ECD is expressed as a 577 amino acid protein consisting of Leu22 - Asp369 region of FGFR4 (Uniprot accession #P22455 - isoform 1) and a C-terminal Fc fusion from human IgG1, which exists as a dimer under non-reducing condition. |
- Specification
- Gene Information
- Related Products
Source : | Human cells |
Species : | Human |
Tag : | Fc |
Form : | Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule) |
Bio-activity : | Binds and inhibits aFGF / FGF-acidic dependent proliferation of mouse fibroblast cells with an ED50 of 0.01 - 0.05 μg/ml |
Molecular Mass : | Calculated molecular mass (kDa): 64.1; Estimated by SDS-PAGE under reducing condition (kDa): 75-85 |
AA Sequence : | LEASEEVELEPCLAPSLEQQEQELT VALGQPVRLCCGRAERGGHWYKEGS RLAPAGRVRGWRGRLEIASFLPED AGRYLCLARGSMIVLQNLTLITGDS LTSSNDDEDPKSHRDPSNRHSYPQQ APYWTHPQRMEKKLHAVPAGNTVK FRCPAAGNPTPTIRWLKDGQAFHGE NRIGGIRLRHQHWSLVMESVVPSDR GTYTCLVENAVGSIRYNYLLDVLE RSPHRPILQAGLPANTTAVVGSDVE LLCKVYSDAQPHIQWLKHIVINGSS FGADGFPYVQVLKTADINSSEVEV LYLRNVSAEDAGEYTCLAGNSIGLS YQSAWLTVLPEEDPTWTAAAPEARY TDGSTGTHTCPPCPAPELLGGPSV FLFPPKPKDTLMISRTPEVTCVVVD VSHEDPEVKFNWYVDGVEVHNAKTK PREEQYNSTYRVVSVLTVLHQDWL NGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVS LTCLVKGFYPSDIAVEWESNGQPE NNYKTTPPVLDSDGSFFLYSKLTVD KSRWQQGNVFSCSVMHEALHNHYTQ KSLSLSPGK |
Endotoxin : | <0.1 eu per 1 μg of purified recombinant protein determined by the |
Purity : | >95% judged by SDS-PAGE under reducing condition |
Storage : | The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles. |
Gene Name : | FGFR4 fibroblast growth factor receptor 4 [ Homo sapiens ] |
Official Symbol : | FGFR4 |
Synonyms : | FGFR4; fibroblast growth factor receptor 4; CD334; JTK2; FGFR-4; tyrosylprotein kinase; protein-tyrosine kinase; hydroxyaryl-protein kinase; tyrosine kinase related to fibroblast growth factor receptor; TKF; MGC20292; |
Gene ID : | 2264 |
mRNA Refseq : | NM_002011 |
Protein Refseq : | NP_002002 |
MIM : | 134935 |
UniProt ID : | P22455 |
Chromosome Location : | 5q33-qter |
Pathway : | Downstream signaling of activated FGFR, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; FGF signaling pathway, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR4 ligand binding and activation, organism-specific biosystem; FRS2-mediated cascade, organism-specific biosystem; |
Function : | ATP binding; fibroblast growth factor 1 binding; fibroblast growth factor 2 binding; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; fibroblast growth factor-activated receptor activity; heparin binding; nucleotide binding; protein tyrosine kinase activity; receptor activity; |
Products Types
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FGFR4-4141H | Active Recombinant Human FGFR4 Protein, GST/His-tagged | +Inquiry |
FGFR4-248H | Recombinant Human FGFR4 Protein, His-tagged | +Inquiry |
FGFR4-94H | Recombinant Active Human FGFR4 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
◆ Lysates | ||
FGFR4-1907HCL | Recombinant Human FGFR4 cell lysate | +Inquiry |
FGFR4-1516RCL | Recombinant Rat FGFR4 cell lysate | +Inquiry |
FGFR4-2757MCL | Recombinant Mouse FGFR4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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