Recombinant Human APOE Protein, His-tagged

• Cat.No.: APOE-17H
• Product Overview: Recombinant human APOE protein with a His-tag was expressed in HEK293

Specification

• Description: The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
• Source: HEK293
• Species: Human
• Tag: His
• Molecular Mass: The protein has a calculated MW of 35 kDa.
• AA Sequence: KVEQAVETEPEPELRQQTEWQSGQR WELALGRFWDYLRWVQTLSEQVQEE LLSSQVTQELRALMDETMKELKAYK SELEEQLTPVAEETRARLSKELQAA QARLGADMEDVCGRLVQYRGEVQAM LGQSTEELRVRLASHLRKLRKRLLR DADDLQKRLAVYQAGAREGAERGLS AIRERLGPLVEQGRVRAATVGSLAG QPLQERAQAWGERLRARMEEMGSRT RDRLDEVKEQVAEVRAKLEEQAQQI RLQAEAFQARLKSWFEPLVEDMQRQ WAGLVEKVQAAVGTSAAPVPSDNHV DHHHHHH
• Endotoxin: <1 EU/μg
• Purity: >95% by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4, 5% trehalose, 5% manitol

Gene Information

• Gene Name: APOE apolipoprotein E [ Homo sapiens (human) ]
• Official Symbol: APOE
• Synonyms: APOE; apolipoprotein E; AD2, Alzheimer disease 2 (APOE*E4 associated, late onset); apo-E; apolipoprotein E3; AD2; LPG; LDLCQ5; MGC1571
• Gene ID: 348
• mRNA Refseq: NM_000041
• Protein Refseq: NP_000032
• MIM: 107741
• UniProt ID: P02649