Recombinant Human GLRX

• Cat.No.: GLRX-78H

Specification

• Description: This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.
• Species: Human
• Form: Lyophilized from 50 mM potassium phosphate, 0.1 mM EDTA, and 80 mM sodium chloride, pH 6.8
• Bio-activity: 240 Units/ mg
• Stability: 6 months
• Storage: 4 centigrade
• Concentration: Concentration of glutaredoxin before lyophilization was 15.6 mg/ml
• Reconstitution: Reconstitute with water or buffer (300 µl will give 70 µM Grx1).
• Publication:
  Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates (2019)

Gene Information

• Gene Name: GLRX glutaredoxin (thioltransferase) [ Homo sapiens ]
• Official Symbol: GLRX
• Synonyms: GRX; GRX1; glutaredoxin-1; TTase-1; thioltransferase-1
• Gene ID: 2745
• mRNA Refseq: NM_001118890
• Protein Refseq: NP_001112362
• MIM: 600443
• UniProt ID: P35754
• Chromosome Location: 5q14
• Pathway: Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; ascorbate recycling (cytosolic), organism-specific biosystem
• Function: electron carrier activity; glutathione disulfide oxidoreductase activity; glutathione oxidoreductase activity