Recombinant Human IAPP protein, MYC/DDK-tagged

• Cat.No.: IAPP-28H
• Product Overview: Recombinant Human IAPP fussed with MYC/DDK tag at C-terminal was expressed in HEK293 cells.

Specification

• Description: Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.
• Source: HEK293 cells
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 3.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: IAPP islet amyloid polypeptide [ Homo sapiens ]
• Official Symbol: IAPP
• Synonyms: DAP; IAP; islet amyloid polypeptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin); amylin; diabetes-associated peptide; insulinoma amyloid peptide
• Gene ID: 3375
• mRNA Refseq: NM_000415
• Protein Refseq: NP_000406
• MIM: 147940
• UniProt ID: P10997
• Chromosome Location: 12p12.1
• Pathway: Amyloids, organism-specific biosystem; Calcitonin-like ligand receptors, organism-specific biosystem; Disease, organism-specific biosystem
• Function: hormone activity; identical protein binding; receptor binding