Recombinant Human CD44 protein, GST-tagged

• Cat.No.: CD44-27238TH
• Product Overview: Recombinant Human CD44 (1 a.a. - 699 a.a.) fussed with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 102.63 kDa
• AA Sequence: MDKFWWHAAWGLCLVPLSLAQIDLN ITCRFAGVFHVEKNGRYSISRTEAA DLCKAFNSTLPTMAQMEKALSIGFE TCRYGFIEGHVVIPRIHPNSICAAN NTGVYILTSNTSQYDTYCFNASAPP EEDCTSVTDLPNAFDGPITITIVNR DGTRYVQKGEYRTNPEDIYPSNPTD DDVSSGSSSERSSTSGGYIFYTFST VHPIPDEDSPWITDSTDRIPATSTS SNTISAGWEPNEENEDERDRHLSFS GSGIDDDEDFISSTISTTPRAFDHT KQNQDWTQWNPSHSNPEVLLQTTTR MTDVDRNGTTAYEGNWNPEAHPPLI HHEHHEEEETPHSTSTIQATPSSTT EETATQKEQWFGNRWHEGYRQTPRE DSHSTTGTAAASAHTSHPMQGRTTP SPEDSSWTDFFNPISHPMGRGHQAG RRMDMDSSHSTTLQPTANPNTGLVE DLDRTGPLSMTTQQSNSQSFSTSHE GLEEDKDHPTTSTLTSSNRNDVTGG RRDPNHSEGSTTLLEGYTSHYPHTK ESRTFIPVTSAKTGSFGVTAVTVGD SNSNVNRSLSGDQDTFHPSGGSHTT HGSESDGHSHGSQEGGANTTSGPIR TPQIPEWLIILASLLALALILAVCI AVNSRRRCGQKKKLVINSGNGAVED RKPSGLNGEASKSQEMVHLVNKESS ETPDQFMTADETRNLQNVDMKIGV
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: CD44 CD44 molecule (Indian blood group) [ Homo sapiens ]
• Official Symbol: CD44
• Synonyms: IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; CD44 antigen; GP90 lymphocyte homing/adhesion receptor; Hermes antigen; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; epican; extracellular matrix receptor III; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; homing function and Indian blood group system; hyaluronate receptor; phagocytic glycoprotein 1; soluble CD44
• Gene ID: 960
• mRNA Refseq: NM_000610
• Protein Refseq: NP_000601
• MIM: 107269
• UniProt ID: P16070
• Chromosome Location: 11p13
• Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem
• Function: collagen binding; contributes_to cytokine receptor activity; contributes_to cytokine receptor activity