Active Recombinant Human ERBB3, Fc-tagged, Biotinylated
Cat.No. : | ERBB3-621H |
Product Overview : | Expressed as a 860 amino acid protein consisting of Ser20-Thr643 region of HER3 and a C-terminal Fc Fusion from human IgG1, which exists as a dimmer under non-reducing condition. |
- Specification
- Gene Information
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Source : | Human cells |
Species : | Human |
Tag : | Fc |
Form : | Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier and preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule). |
Bio-activity : | It was reported to inhibit the biological activity of Neuregulin-1 on MCF?7 human breast cancer cells. |
Molecular Mass : | Calculated molecular mass (kDa): 95.1; Estimated by SDS-PAGE under reducing condition (kDa): 98 |
AA Sequence : | SEVGNSQAVCPGTLNGLSVTGDAEN QYQTLYKLYERCEVVMGNLEIVLTG HNADLSFLQWIREVTGYVLVAMNEF STLPLPNLRVVRGTQVYDGKFAIFV MLNYNTNSSHALRQLRLTQLTEILS GGVYIEKNDKLCHMDTIDWRDIVR DRDAEIVVKDNGRSCPPCHEVCKGR CWGPGSEDCQTLTKTICAPQCNGHC FGPNPNQCCHDECAGGCSGPQDTD CFACRHFNDSGACVPRCPQPLVYNK LTFQLEPNPHTKYQYGGVCVASCPH NFVVDQTSCVRACPPDKMEVDKNG LKMCEPCGGLCPKACEGTGSGSRFQ TVDSSNIDGFVNCTKILGNLDFLIT GLNGDPWHKIPALDPEKLNVFRTV REITGYLNIQSWPPHMHNFSVFSNL TTIGGRSLYNRGFSLLIMKNLNVTS LGFRSLKEISAGRIYISANRQLCY HHSLNWTKVLRGPTEERLDIKHNRP RRDCVAEGKVCDPLCSSGGCWGPGP GQCLSCRNYSRGGVCVTHCNFLNG EPREFAHEAECFSCHPECQPMEGTA TCNGSGSDTCAQCAHFRDGPHCVSS CPHGVLGAKGPIYKYPDVQNECRP CHENCTQGCKGPELQDCLGQTLVLI GKTHLTSTGDEPKSCDKTHTCPPCP APELLGGPSVFLFPPKPKDTLMIS RTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYNSTYRVVS VLTVLHQDWLNGKEYKCKVSNKAL PAPIEKTISKAKGQPREPQVYTLPP SREEMTKNQVSLTCLVKGFYPSDIA VEWESNGQPENNYKTTPPVLDSDG SFFLYSKLTVDKSRWQQGNVFSCSV MHEALHNHYTQKSLSLSPGK |
Endotoxin : | <0.1 eu per 1 μg of purified recombinant protein determined by the lal>0.1> |
Purity : | >95% judged by SDS-PAGE under reducing condition |
Storage : | The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles. |
Gene Name : | ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Homo sapiens ] |
Official Symbol : | ERBB3 |
Synonyms : | ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033; |
Gene ID : | 2065 |
mRNA Refseq : | NM_001005915 |
Protein Refseq : | NP_001005915 |
MIM : | 190151 |
UniProt ID : | P21860 |
Chromosome Location : | 12q13 |
Pathway : | Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Downregulation of ERRB2:ERBB3 signaling, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; ErbB receptor signaling network, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; |
Function : | ATP binding; growth factor binding; growth factor binding; nucleotide binding; protein binding; protein heterodimerization activity; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; NOT protein tyrosine kinase activity; receptor activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; |
Products Types
◆ Recombinant Protein | ||
ERBB3-238H | Recombinant Human ERBB3 Protein, Strep-tagged | +Inquiry |
ERBB3-44H | Active Recombinant Human ERBB3(Ser20-Thr643), Fc-tagged | +Inquiry |
Erbb3-384M | Recombinant Mouse Erbb3 Protein, His-tagged | +Inquiry |
ERBB3-237H | Recombinant Human ERBB3 Protein, Fc-tagged | +Inquiry |
Erbb3-43M | Recombinant Mouse Erbb3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ERBB3-939HCL | Recombinant Human ERBB3 cell lysate | +Inquiry |
ERBB3-1415RCL | Recombinant Rat ERBB3 cell lysate | +Inquiry |
ERBB3-1765MCL | Recombinant Mouse ERBB3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPotential side effects may include skin rash, diarrhea, and cardiovascular issues, as seen with other drugs targeting the EGFR family.
ERBB3 activation has been associated with resistance to some targeted therapies, such as EGFR inhibitors, making it a challenging target in cancer treatment.
ERBB3 can form heterodimers with other EGFR family members, such as EGFR and HER2, leading to the activation of downstream signaling pathways.
Yes, elevated ERBB3 expression has been linked to poor prognosis in certain cancers, serving as a potential biomarker for patient outcomes.
ERBB3 overexpression is frequently observed in breast, ovarian, and gastric cancers, among others.
Customer Reviews (3)
Write a reviewTheir expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.
Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.
The ERBB3 protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.
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