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Active Recombinant Human ERBB3, Fc-tagged, Biotinylated

Cat.No. : ERBB3-621H
Product Overview : Expressed as a 860 amino acid protein consisting of Ser20-Thr643 region of HER3 and a C-terminal Fc Fusion from human IgG1, which exists as a dimmer under non-reducing condition.
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Source : Human cells
Species : Human
Tag : Fc
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier and preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity : It was reported to inhibit the biological activity of Neuregulin-1 on MCF?7 human breast cancer cells.
Molecular Mass : Calculated molecular mass (kDa): 95.1; Estimated by SDS-PAGE under reducing condition (kDa): 98
AA Sequence : SEVGNSQAVCPGTLNGLSVTGDAEN QYQTLYKLYERCEVVMGNLEIVLTG HNADLSFLQWIREVTGYVLVAMNEF STLPLPNLRVVRGTQVYDGKFAIFV MLNYNTNSSHALRQLRLTQLTEILS GGVYIEKNDKLCHMDTIDWRDIVR DRDAEIVVKDNGRSCPPCHEVCKGR CWGPGSEDCQTLTKTICAPQCNGHC FGPNPNQCCHDECAGGCSGPQDTD CFACRHFNDSGACVPRCPQPLVYNK LTFQLEPNPHTKYQYGGVCVASCPH NFVVDQTSCVRACPPDKMEVDKNG LKMCEPCGGLCPKACEGTGSGSRFQ TVDSSNIDGFVNCTKILGNLDFLIT GLNGDPWHKIPALDPEKLNVFRTV REITGYLNIQSWPPHMHNFSVFSNL TTIGGRSLYNRGFSLLIMKNLNVTS LGFRSLKEISAGRIYISANRQLCY HHSLNWTKVLRGPTEERLDIKHNRP RRDCVAEGKVCDPLCSSGGCWGPGP GQCLSCRNYSRGGVCVTHCNFLNG EPREFAHEAECFSCHPECQPMEGTA TCNGSGSDTCAQCAHFRDGPHCVSS CPHGVLGAKGPIYKYPDVQNECRP CHENCTQGCKGPELQDCLGQTLVLI GKTHLTSTGDEPKSCDKTHTCPPCP APELLGGPSVFLFPPKPKDTLMIS RTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYNSTYRVVS VLTVLHQDWLNGKEYKCKVSNKAL PAPIEKTISKAKGQPREPQVYTLPP SREEMTKNQVSLTCLVKGFYPSDIA VEWESNGQPENNYKTTPPVLDSDG SFFLYSKLTVDKSRWQQGNVFSCSV MHEALHNHYTQKSLSLSPGK
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
Purity : >95% judged by SDS-PAGE under reducing condition
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name : ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Homo sapiens ]
Official Symbol : ERBB3
Synonyms : ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033;
Gene ID : 2065
mRNA Refseq : NM_001005915
Protein Refseq : NP_001005915
MIM : 190151
UniProt ID : P21860
Chromosome Location : 12q13
Pathway : Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Downregulation of ERRB2:ERBB3 signaling, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; ErbB receptor signaling network, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem;
Function : ATP binding; growth factor binding; growth factor binding; nucleotide binding; protein binding; protein heterodimerization activity; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; NOT protein tyrosine kinase activity; receptor activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the potential side effects of targeting ERBB3 in cancer therapy? 03/08/2023

Potential side effects may include skin rash, diarrhea, and cardiovascular issues, as seen with other drugs targeting the EGFR family.

How does ERBB3 contribute to resistance to certain cancer therapies? 01/29/2023

ERBB3 activation has been associated with resistance to some targeted therapies, such as EGFR inhibitors, making it a challenging target in cancer treatment.

How does ERBB3 interact with other receptors in the EGFR family? 11/07/2022

ERBB3 can form heterodimers with other EGFR family members, such as EGFR and HER2, leading to the activation of downstream signaling pathways.

Can ERBB3 be used as a biomarker for prognosis in cancer patients? 10/26/2022

Yes, elevated ERBB3 expression has been linked to poor prognosis in certain cancers, serving as a potential biomarker for patient outcomes.

In which types of cancers is ERBB3 commonly overexpressed? 10/19/2020

ERBB3 overexpression is frequently observed in breast, ovarian, and gastric cancers, among others.

Customer Reviews (3)

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Reviews
10/28/2021

    Their expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.

    08/11/2021

      Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.

      03/03/2020

        The ERBB3 protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.

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