Active Recombinant Human LTBR, Fc-tagged, Biotinylated
Cat.No. : | LTBR-636H |
Product Overview : | The recombinant human LTβR-Fc fusion is expressed as a 420 amino acid protein consisting of Gln31 - Thr234 region of LTβR (UniProt accession #P36941) and a C-terminal Fc from human IgG1, which exists as a dimer/tetramer/oligomer under non-reducing conditions. |
- Specification
- Gene Information
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Source : | Human cells |
Species : | Human |
Tag : | Fc |
Form : | Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule). |
Bio-activity : | Binds to its ligand LIGHT and lymphotoxin-α1/β2. Inhibits LIGHT/lymphotoxin-α1/β2-mediated biological activities including NF-κB activation and cytotoxicity. |
Molecular Mass : | Calculated molecular mass (kDa): 46.8; Estimated by SDS-PAGE under reducing condition (kDa): 55-60 |
Endotoxin : | <0.1 eu per 1 μg of purified recombinant protein determined by the lal>0.1> |
Purity : | >95% judged by SDS-PAGE under reducing condition |
Storage : | The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles. |
Gene Name : | LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) [ Homo sapiens ] |
Official Symbol : | LTBR |
Synonyms : | LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3); D12S370; tumor necrosis factor receptor superfamily member 3; TNF R III; TNFCR; TNFR RP; TNFR2 RP; TNFRSF3; TNF-RIII; TNFR-III; lymphotoxin B receptor; lymphotoxin-beta receptor; TNFR superfamily, member 3; tumor necrosis factor C receptor; tumor necrosis factor receptor type III; tumor necrosis factor receptor 2-related protein; tumor necrosis factor receptor superfamily, member 3; CD18; TNFR-RP; TNFR2-RP; LT-BETA-R; TNF-R-III; |
Gene ID : | 4055 |
mRNA Refseq : | NM_002342 |
Protein Refseq : | NP_002333 |
MIM : | 600979 |
UniProt ID : | P36941 |
Chromosome Location : | 12p13 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; |
Function : | identical protein binding; protein binding; receptor activity; |
Products Types
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◆ Lysates | ||
LTBR-1229CCL | Recombinant Cynomolgus LTBR cell lysate | +Inquiry |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionTherapeutic strategies targeting LTBR include inhibition of its signaling pathways, modulation of immune response, and anti-cancer approaches. Inhibitors of the NF-κB pathway, such as small molecule inhibitors or neutralizing antibodies, can be used to block LTBR-mediated signaling and reduce inflammation or tumor growth.
Current research on LTBR aims to further elucidate its role in disease mechanisms, particularly in autoimmune disorders, chronic inflammation, and cancer. Studies are investigating the downstream effects of LTBR activation, its involvement in immune cell function, and the identification of potential therapeutic targets within the LTBR signaling pathway.
The expression of LTBR is regulated by transcription factors and signaling pathways. For example, NF-κB and AP-1 transcription factors can bind to the promoter region of LTBR gene and enhance its expression. Additionally, cytokines and growth factors can also influence LTBR expression through downstream signaling cascades.
The LTBR signaling pathway interacts with various other signaling pathways, including those activated by TNFR1, TNFR2, and CD40. These interactions can lead to crosstalk and amplification of signaling, resulting in enhanced cellular responses. Understanding these interactions is crucial for elucidating the complex network of signaling events involved in disease pathogenesis.
LTBR, a membrane protein belonging to the tumor necrosis factor receptor superfamily, regulates various cellular processes such as inflammation, immune response, and lymphoid organ development. It activates signaling pathways including the NF-κB pathway and non-canonical NF-κB pathway.
Yes, certain genetic variants have been identified that are associated with altered LTBR expression and disease susceptibility. These variants can affect the binding of transcription factors or alter the stability of LTBR mRNA, leading to dysregulation of LTBR expression and increased risk of certain diseases.
Future research directions in LTBR include exploring the molecular mechanisms underlying LTBR-mediated signaling, investigating the impact of LTBR genetic variants on disease susceptibility, and developing novel therapeutic strategies targeting LTBR. Additionally, studying the interplay between LTBR and other signaling pathways may uncover new insights into disease pathogenesis and identify new therapeutic avenues.
Customer Reviews (3)
Write a reviewUnrivaled in efficiency, this innovative elixir leaves me awestruck.
By using this reagent, I can better investigate protein interactions.
The interpretation of the results provided by this reagent is clear, allowing me to better understand the experimental outcomes.
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