Active Recombinant Human NNMT protein, His-tagged
Cat.No. : | NNMT-148H |
Product Overview : | Recombinant Human NNMT(Met1-Leu264) fused with His tag at C-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | NNMT (Nicotinamide NMethyltransferase) is a cytosolic enzyme that catalyzes the Nmethylation of nicotinamide and other pyridines using SadenosylLmethionine (AdoMet) as the methyl group donor. The enzyme is highly expressed in liver but is also detected in other organs. NNMT plays a significant role in nicotinamide metabolism and in the detoxification of xenobiotics. The association with thyroid cancer and renal carcinoma makes NNMT useful as a tumor biomarker. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Met1 |
Form : | Supplied as a 0.2 µm filtered solution in Tris, NaCl and Glycerol. |
Bio-activity : | Measured by its ability to methylate nicotinamide. The specific activity is >65 pmol/min/µg. |
Molecular Mass : | Predicted Molecular Mass: 30 kDa;SDS-PAGE: 25-29 kDa, reducing conditions. |
Endotoxin : | < 1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane. |
Stability : | Avoid repeated freeze-thaw cycles.6 months from date of receipt, -70 centigrade as supplied.3 months, -70 centigrade under sterile conditions after opening. |
Gene Name : | NNMT nicotinamide N-methyltransferase [ Homo sapiens ] |
Official Symbol : | NNMT |
Synonyms : | NNMT; nicotinamide N-methyltransferase; |
Gene ID : | 4837 |
mRNA Refseq : | NM_006169 |
Protein Refseq : | NP_006160 |
MIM : | 600008 |
UniProt ID : | P40261 |
Chromosome Location : | 11q23.1 |
Pathway : | Biological oxidations, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Methylation, organism-specific biosystem; Nicotinate and nicotinamide metabolism, organism-specific biosystem; Nicotinate and nicotinamide metabolism, conserved biosystem; Phase II conjugation, organism-specific biosystem; |
Function : | methyltransferase activity; nicotinamide N-methyltransferase activity; transferase activity; |
Products Types
◆ Recombinant Protein | ||
NNMT-017H | Recombinant Human NNMT Protein, His/SUMO-tagged | +Inquiry |
NNMT-234H | Active Recombinant Human NNMT Protein, His-tagged, Bioactivity Validated | +Inquiry |
NNMT-780H | Recombinant Human NNMT Protein, His-tagged | +Inquiry |
NNMT-5956H | Recombinant Human NNMT Protein, GST-tagged | +Inquiry |
Nnmt-4449M | Recombinant Mouse Nnmt Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
NNMT-3779HCL | Recombinant Human NNMT 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2215 | N'-Nicotinamide Methyltransferase (NNMT) Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
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Q&As (5)
Ask a questionYes, elevated levels of NNMT in blood or tissues have been proposed as potential biomarkers for certain diseases.
Elevated NNMT levels have been associated with increased risk of cardiovascular diseases, making it a potential therapeutic target.
Research is ongoing to develop drugs that modulate NNMT activity as potential treatments for diseases where NNMT is implicated.
NNMT has been linked to several diseases and health conditions, making it a potential target for therapeutic interventions.
NNMT dysregulation has been associated with metabolic disorders, cancer, neurodegenerative diseases, and cardiovascular diseases.
Customer Reviews (3)
Write a reviewIts high specificity and functional integrity ensure accurate and reproducible data, allowing researchers to draw meaningful conclusions from their experiments.
This protein is known for its exceptional quality and purity, providing reliable and consistent results.
The NNMT protein offers numerous advantages in trials and research experiments, making it an excellent choice for researchers.
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