| Description : |
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural andfunctional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylatedCpG dinucleotides in bacterial DNA to mount an innate immune response. |
| Source : |
Wheat Germ |
| Species : |
Human |
| Form : |
25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
| Molecular Mass : |
113.52 kDa |
| AA Sequence : |
MGFCRSALHPLSLLVQAIMLAMTLA LGTLPAFLPCELQPHGLVNCNWLFL KSVPHFSMAAPRGNVTSLSLSSNRI HHLHDSDFAHLPSLRHLNLKWNCPP VGLSPMHFPCHMTIEPSTFLAVPTL EELNLSYNNIMTVPALPKSLISLSL SHTNILMLDSASLAGLHALRFLFMD GNCYYKNPCRQALEVAPGALLGLGN LTHLSLKYNNLTVVPRNLPSSLEYL LLSYNRIVKLAPEDLANLTALRVLD VGGNCRRCDHAPNPCMECPRHFPQL HPDTFSHLSRLEGLVLKDSSLSWLN ASWFRGLGNLRVLDLSENFLYKCIT KTKAFQGLTQLRKLNLSFNYQKRVS FAHLSLAPSFGSLVALKELDMHGIF FRSLDETTLRPLARLPMLQTLRLQM NFINQAQLGIFRAFPGLRYVDLSDN RISGASELTATMGEADGGEKVWLQP GDLAPAPVDTPSSEDFRPNCSTLNF TLDLSRNNLVTVQPEMFAQLSHLQC LRLSHNCISQAVNGSQFLPLTGLQV LDLSHNKLDLYHEHSFTELPRLEAL DLSYNSQPFGMQGVGHNFSFVAHLR TLRHLSLAHNNIHSQVSQQLCSTSL RALDFSGNALGHMWAEGDLYLHFFQ GLSGLIWLDLSQNRLHTLLPQTLRN LPKSLQVLRLRDNYLAFFKWWSLHF LPKLEVLDLAGNQLKALTNGSLPAG TRLRRLDVSCNSISFVAPGFFSKAK ELRELNLSANALKTVDHSWFGPLAS ALQILDVSANPLHCACGAAFMDFLL EVQAAVPGLPSRVKCGSPGQLQGLS IFAQDLRLCLDEALSWDCFALSLLA VALGLGVPMLHHLCGWDLWYCFHLC LAWLPWRGRQSGRDEDALPYDAFVV FDKTQSAVADWVYNELRGQLEECRG RWALRLCLEERDWLPGKTLFENLWA SVYGSRKTLFVLAHTDRVSGLLRAS FLLAQQRLLEDRKDVVVLVILSPDG RRSRYVRLRQRLCRQSVLLWPHQPS GQRSFWAQLGMALTRDNHHFYNRNF CQGPTAE |
| Applications : |
Antibody Production;Functional Study: Recommended usage only, not validated yet;Compound Screening: Recommended usage only, not validated yet. |
| Notes : |
Heating may cause protein aggregation. Please do not heat this product before electrophoresis. Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
