Active Recombinant Human Histone Deacetylase 6, GST-tagged

• Cat.No.: HDAC6-397H
• Product Overview: Full Length Human HDAC6–Class IIb, 160kD with GST tag.

Specification

• Cat. No.: HDAC6-397H
• Description: Histone deacetylase 6, also known as HDAC6, is a human gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
• Source: HDAC6 was cloned from human heart cDNA and expressed in insect cells using a baculoviral expression system.
• Purity: Purified, active enzyme.
• Purification Procedure: Glutathione Column
• Activity: 1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C.
• Stability/Shelf-life: >6 months from date of shipment
• Buffer Composition: 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol.
• Storage: –80°C

Gene Information

• Gene Name: HDAC6 histone deacetylase 6 [ Homo sapiens ]
• Synonyms: HDAC6; FLJ16239; HD6; JM21; histone deacetylase 6; OTTHUMP00000032398; EC 3.5.1.98; KIAA0901.
• Gene ID: 10013
• mRNA Refseq: NM_006044
• Protein Refseq: NP_006035
• MIM: 300272
• UniProt ID: Q9UBN7
• Chromosome Location: Xp11.23
• Pathway: Gene Expression
• Function: actin binding; histone deacetylase activity; histone deacetylase binding; hydrolase activity; metal ion binding; specific transcriptional repressor activity; tubulin deacetylase activity; zinc ion binding