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Recombinant Human interferon regulatory factor 1, His-tagged

Cat.No. : IRF1-25H
Product Overview : Recombinant Human Interferon Regulatory Factor-1 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 134 amino acids (1-114) with a His Tag of 20 aa, and having a molecular mass of 15 kDa. The IRF-1 is purified by proprietary chromatographic techniques.
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Cat. No. : IRF1-25H
Description : IRF1, Interferon regulatory factor 1, is a member of the interferon regulatory transcription factor (IRF) family which regulates gene expression critical to immune response, hematopoiesis and proliferation. IRF-1 is a transcriptional activator for IFN-A, IFN-B, and IFN-G stimulated genes. IRF1 is also a tumor suppressor transcription factor inducing apoptosis of tumorigenic cell lines.
Source : Escherichia Coli.
Amino Acid Sequence : MGSSHHHHHH SSGLVPRGSH MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKHAAKHGWDINK DACLFRSWAI HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN KGSSAVRVYR MLPP
Physical Appearance : Sterile Filtered colorless solution.
Purity : Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : 1 mg/ml in 20mM Tris pH-8 and 10% glycerol.
Storage : Liquid Interferon although stable at 10°Cfor 1 week, should be stored below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : IRF1 interferon regulatory factor 1 [ Homo sapiens ]
Synonyms : IRF1; interferon regulatory factor 1; MAR; IRF-1; OTTHUMP00000198266; interferon regulatory factor-1
Gene ID : 3659
mRNA Refseq : NM_002198
Protein Refseq : NP_002189
MIM : 147575
UniProt ID : P10914
Chromosome Location : 5q23-q31
Function : sequence-specific DNA binding; transcription factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How do changes in IRF1 expression or function affect responses to bacterial infections? 06/19/2022

Variations in IRF1 impact the body's response to bacterial infections.

How does IRF1 impact the pathogenesis of autoimmune diseases? 08/01/2021

IRF1 may play a key role in the development of autoimmune diseases.

What role does IRF1 play in antiviral defense mechanisms? 02/09/2021

IRF1 is crucial in antiviral defenses, enhancing response to viral infections.

How does IRF1 regulate gene expression in the immune response? 12/13/2020

IRF1 activates immune response genes, especially interferon-responsive genes.

What is the effect of IRF1 on tumor suppression and cancer cell proliferation? 07/01/2019

IRF1 acts as a tumor suppressor, inhibiting cancer cell growth.

How does IRF1 influence the development and function of T cells and NK cells? 04/09/2018

IRF1 affects the development and function of T cells and NK cells.

How does IRF1 modulate inflammatory responses and cytokine production? 03/27/2018

IRF1 regulates inflammation and cytokine production.

Customer Reviews (3)

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Reviews
10/19/2021

    Swift protein expression optimization, boosts our research productivity.

    05/03/2020

      Accurate protein structural characterization, a cornerstone of our studies.

      11/01/2019

        High-quality protein sequencing, invaluable for our scientific work.

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