Recombinant Human Nicotinamide N-methyltransferase, His-tagged
Cat.No. : | NNMT-143H |
Product Overview : | Recombinant human NNMT protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography, 31.7 kDa (284aa). |
- Specification
- Gene Information
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Cat. No. : | NNMT-143H |
Description : | NNMT(Nicotinamide N-methyltransferase) belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. It is predominantly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. NNMT catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. |
Source : | Escherichia Coli. |
Form : | Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol. |
Purity : | > 95% by SDS - PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MESGFTSKDT YLSHFNPRDYLEKYYKFGSR HSAESQILKH LLKNLFKIFC LDGVKGDLLI DIGSGPTIYQLL SAC E SFKE IVVTD YSDQN LQELEKWLKK EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG AVPLPPADCVLSTLCLDAAC PDLPTYCRAL RNLGSLLKPG GFLVIMDALK SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ SYSSTMANNEGLFSLVARKL SRPL |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Publication : |
Noncompetitive Inhibition of Indolethylamine N-Methyltransferase by N, N Dimethyltryptamine (DMT) and N, N-Dimethylaminopropyltryptamine (2014)
|
Gene Name : | NNMT nicotinamide N-methyltransferase [ Homo sapiens ] |
Synonyms : | NNMT; nicotinamide N-methyltransferase; EC 2.1.1.1. |
Gene ID : | 4837 |
mRNA Refseq : | NM_006169 |
Protein Refseq : | NP_006160 |
MIM : | 600008 |
UniProt ID : | P40261 |
Chromosome Location : | 11q23.1 |
Pathway : | Nicotinate and nicotinamide metabolism ; Biological oxidations |
Function : | methyltransferase activity; nicotinamide N-methyltransferase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
Nnmt-781M | Recombinant Mouse Nnmt Protein, His-tagged | +Inquiry |
NNMT-034H | Recombinant Human NNMT Protein, His/SUMO-tagged | +Inquiry |
NNMT-234H | Active Recombinant Human NNMT Protein, His-tagged, Bioactivity Validated | +Inquiry |
Nnmt-4449M | Recombinant Mouse Nnmt Protein, Myc/DDK-tagged | +Inquiry |
NNMT-017H | Recombinant Human NNMT Protein, His/SUMO-tagged | +Inquiry |
◆ Lysates | ||
NNMT-3779HCL | Recombinant Human NNMT 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2215 | N'-Nicotinamide Methyltransferase (NNMT) Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, elevated levels of NNMT in blood or tissues have been proposed as potential biomarkers for certain diseases.
Elevated NNMT levels have been associated with increased risk of cardiovascular diseases, making it a potential therapeutic target.
Research is ongoing to develop drugs that modulate NNMT activity as potential treatments for diseases where NNMT is implicated.
NNMT has been linked to several diseases and health conditions, making it a potential target for therapeutic interventions.
NNMT dysregulation has been associated with metabolic disorders, cancer, neurodegenerative diseases, and cardiovascular diseases.
Customer Reviews (3)
Write a reviewIts high specificity and functional integrity ensure accurate and reproducible data, allowing researchers to draw meaningful conclusions from their experiments.
This protein is known for its exceptional quality and purity, providing reliable and consistent results.
The NNMT protein offers numerous advantages in trials and research experiments, making it an excellent choice for researchers.
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