Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human Nicotinamide N-methyltransferase, His-tagged

Cat.No. : NNMT-143H
Product Overview : Recombinant human NNMT protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography, 31.7 kDa (284aa).
  • Specification
  • Gene Information
  • Related Products
Cat. No. : NNMT-143H
Description : NNMT(Nicotinamide N-methyltransferase) belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. It is predominantly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. NNMT catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
Source : Escherichia Coli.
Form : Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol.
Purity : > 95% by SDS - PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MESGFTSKDT YLSHFNPRDYLEKYYKFGSR HSAESQILKH LLKNLFKIFC LDGVKGDLLI DIGSGPTIYQLL SAC E SFKE IVVTD YSDQN LQELEKWLKK EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG AVPLPPADCVLSTLCLDAAC PDLPTYCRAL RNLGSLLKPG GFLVIMDALK SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ SYSSTMANNEGLFSLVARKL SRPL
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Publication :
Noncompetitive Inhibition of Indolethylamine N-Methyltransferase by N, N Dimethyltryptamine (DMT) and N, N-Dimethylaminopropyltryptamine (2014)
Gene Name : NNMT nicotinamide N-methyltransferase [ Homo sapiens ]
Synonyms : NNMT; nicotinamide N-methyltransferase; EC 2.1.1.1.
Gene ID : 4837
mRNA Refseq : NM_006169
Protein Refseq : NP_006160
MIM : 600008
UniProt ID : P40261
Chromosome Location : 11q23.1
Pathway : Nicotinate and nicotinamide metabolism ; Biological oxidations
Function : methyltransferase activity; nicotinamide N-methyltransferase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can NNMT protein be used as a biomarker for diseases? 04/18/2023

Yes, elevated levels of NNMT in blood or tissues have been proposed as potential biomarkers for certain diseases.

How does NNMT affect cardiovascular health? 07/01/2022

Elevated NNMT levels have been associated with increased risk of cardiovascular diseases, making it a potential therapeutic target.

Are there any drugs targeting NNMT protein? 08/15/2019

Research is ongoing to develop drugs that modulate NNMT activity as potential treatments for diseases where NNMT is implicated.

How is NNMT protein clinically relevant? 04/11/2017

NNMT has been linked to several diseases and health conditions, making it a potential target for therapeutic interventions.

What diseases are associated with NNMT dysfunction? 06/10/2016

NNMT dysregulation has been associated with metabolic disorders, cancer, neurodegenerative diseases, and cardiovascular diseases.

Customer Reviews (3)

Write a review
Reviews
01/22/2021

    Its high specificity and functional integrity ensure accurate and reproducible data, allowing researchers to draw meaningful conclusions from their experiments.

    11/10/2018

      This protein is known for its exceptional quality and purity, providing reliable and consistent results.

      01/25/2017

        The NNMT protein offers numerous advantages in trials and research experiments, making it an excellent choice for researchers.

        Ask a Question for All NNMT Products

        Required fields are marked with *

        My Review for All NNMT Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends