Recombinant Human VAMP2

• Cat.No.: VAMP2-216H
• Product Overview: Recombinant Human VAMP2 produced inE.Coliis a single, non-glycosylated polypeptide chain. The protein contains 126 amino acids and has a molecular mass of 13.8 kDa.

Specification

• Cat. No.: VAMP2-216H
• Description: Synaptobrevin 2 which is an 18 kDa integral membrane protein localized to the cytoplasmic surface of synaptic vesicle, consists of a proline-rich N-terminal region, a highly conserved hydrophilic domain, followed by a transmembrane anchor and a C-terminal. Synaptobrevin 2 is predominantly expressed in Langerhans islets and glomerular cells. The N-terminal domain of the protein (residues 1-89) forms a specific SNARE complex with the target membrane-associated t- or Q-SNAREs syntaxin 1 and SNAP-25.
• Source: Escherichia Coli.
• Amino Acid Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSA TAATAPPAAP AGEGGPPAPP PNLTSNRRLQ QTQAQVDEVV DIMRVNVDKV LERDQKLSEL DDRADALQAG ASQFETSAAKLKRKYW
• Physical Appearance: Sterile Filtered colorless solution.
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: The protein solution (1mg/ml) contains 1X PBS and 1mM EDTA.
• Stability: Synaptobrevin although stable 14°Cfor 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) [ Homo sapiens ]
• Synonyms:
  VAMP2; vesicle-associated membrane protein 2 (synaptobrevin 2); SYB2; VAMP-2; FLJ11460; VAMP2; HGNC:12643; Synaptobrevin-2; synaptobrevin 2; vesicle associated membrane protein 2
• Gene ID: 6844
• mRNA Refseq: NM_014232
• Protein Refseq: NP_055047
• UniProt ID: P63027
• Chromosome Location: 17p13.1
• MIM: 185881
• Pathway: SNARE interactions in vesicular transport; Botulinum neurotoxicity; Diabetes pathways; Integration of energy metabolism; Membrane Trafficking; Synaptic Transmission
• Function: protein binding