Recombinant Human BCL2-associated Agonist Of Cell Death

• Cat.No.: BAD-82H
• Product Overview: Recombinant Human Bcl2 antagonist of cell death (BAD) full length protein expressed inE.coli.

Specification

• Cat. No.: BAD-82H
• Description: The Bcl-2 family of protein is characterized by its ability to modulate cell death under a broad range of physiologic conditions. Bcl-2 and several related proteins function to inhibit apoptosis while other members of the Bcl-2 family, such as Bax and Bak, enhance cell death under various conditions. Bad exhibits homology to Bcl-2 limited to the BH1, but not with Bax, Bcl-xS, Mcl-1, A1 or itself. In mammalian cells, Bad binds with greater affinity to Bcl-xL than to Bcl-2 and reverses the death repressor activity of Bcl-xL but not Bcl-2.
• Source: Escherichia Coli.
• Physical Appearance: Sterile Filtered clear solution.
• Formulation: BAD protein at 100μg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol.
• Applications: • ELISA • Inhibition Assays • Western Blotting.
• Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 51kDa.
• Storage: Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: BAD BCL2-associated agonist of cell death [ Homo sapiens ]
• Synonyms: BAD; BCL2-associated agonist of cell death; BBC2; BCL2L8;Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2- associated death promoter
• Gene ID: 572
• mRNA Refseq: NM_004322
• Protein Refseq: NP_004313
• UniProt ID: Q92934
• Chromosome Location: 11q13.1
• MIM: 603167
• Pathway: cute myeloid leukemia; Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Apoptosis; Chronic myeloid leukemia; Endometrial cancer; ErbB signaling pathway; Focal adhesion; Insulin signaling pathway; Melanoma; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pancreatic cancer; thways in cancer; VEGF signaling pathway; Apoptosis
• Function: otein binding; protein kinase binding