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Recombinant Human ribosomal protein, large, P0

Cat.No. : RPLP0-198H
Product Overview : Recombinant Human Ribosomal Phosphoprotein P0 (His-tagged) produced inSf9is a glycosylated, polypeptide chain. The protein has a molecular mass of 35,096 dalton. The protein is purified by proprietary chromatographic techniques.
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Cat. No. : RPLP0-198H
Description : The ribosomal phosphoproteins, also called P protein antigens, are associated with the large ribosomal subunit and therefore are antigenic targets with a cytoplasmic localization. Three P proteins have been described: P0 with a molecular weight of 35 kDa, P1 (19 kDa) and P2 (17 kDa). Autoantibodies against ribosomal P proteins are present in 10 % of SLE patients. If anti-ribosomal P antibodies were to occur in the absence of other typical SLE associated autoantibodies, they may account for some patients with so-called ANA-negative lupus. It has been reported that lupus patients positive for anti-ribosomal P autoantibodies have a high frequency of CNS involvement, suggesting a marker use for these antibodies.
Source : Sf9 insect cells.
Formulation : Recombinant Human Ribosomal Phosphoprotein P0 is supplied at a of 0.9mg/ml in20mM HEPES buffer pH-7.5, 0.01 mM EDTA. 0.02% SDS.
Immunological Functions : 1. Binds IgG-type human auto-antibodies. 2. Standard ELISA test (checker-board analysis of positive/negative sera panels.
Applications : Western-Blot with monoclonal anti-hexa-His-tag antibody & SLE sera (Systemic Lupus Erythematodes Disease).
Purity : Greater than 80% (SDS-PAGE).
Coating Concentration : 0.3-0.7 µg/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination.
Storage Conditions : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Gene Name : RPLP0 ribosomal protein, large, P0 [ Homo sapiens ]
Synonyms : RPLP0; ribosomal protein, large, P0; P0; L10E; RPP0; PRLP0; MGC88175; MGC111226; RPLP0;60S acidic ribosomal protein P0; acidic ribosomal phosphoprotein P0; ribosomal protein P0; ribosomal protein, large, P0
Gene ID : 6175
mRNA Refseq : NM_001002
Protein Refseq : NP_000993
MIM : 180510
UniProt ID : P05388
Chromosome Location : 12q24.2
Pathway : Ribosome; Gene Expression; Influenza Infection; Metabolism of proteins
Function : RNA binding;protein binding;structural constituent of ribosome

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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