Recombinant Human Von Willebrand Factor
Cat.No. : | VWF-126H |
Product Overview : | Recombinant Humanvon Willebrand factor protein expressed inE.coliencodes amino acids 2597-2791 and has a molecular mass of 48 kDa. |
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- Gene Information
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Cat. No. : | VWF-126H |
Description : | Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. von Willebrand factor is synthesized by endothelial cells and stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial (or megakaryocytic) lineage of neoplasms. As not all endothelial cells synthesize / store) this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence. |
Source : | E.coli. |
Formulation : | Recombinant Human Factor VIII Related Antigen protein at 2µg/20ul 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol. |
Application : | •ELISA •Inhibition Assays •Western Blotting. |
Characterization : | On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 48 kDa. |
Storage & Stability : | Store vial at -20℃ to -80℃. When stored at the recommended temperature, this protein is stable for 12 months. |
Gene Name : | VWF von Willebrand factor [ Homo sapiens ] |
Synonyms : | VWF; von Willebrand factor; von Willebrand antigen 2; von Willebrand antigen II; F8VWF; F8; VWD; vWF; coagulation factor VIII VWF |
Gene ID : | 7450 |
mRNA Refseq : | NM_000552 |
Protein Refseq : | NP_000543 |
MIM : | 193400 |
UniProt ID : | P04275 |
Chromosome Location : | 12p13.3 |
Pathway : | Complement and coagulation cascades; ECM-receptor interaction; Focal adhesion; Hemostasis; Integrin cell surface interactions |
Function : | chaperone binding; collagen binding; glycoprotein binding; immunoglobulin binding; integrin binding; protease binding; protein N-terminus binding; protein homodimerization activity |
Products Types
◆ Recombinant Protein | ||
VWF-2543H | Recombinant Human VWF protein(1491-1900 aa), C-His-tagged | +Inquiry |
VWF-4996R | Recombinant Rhesus Macaque VWF Protein, His (Fc)-Avi-tagged | +Inquiry |
VWF-18420M | Recombinant Mouse VWF Protein, His tagged | +Inquiry |
VWF-10101M | Recombinant Mouse VWF Protein, His (Fc)-Avi-tagged | +Inquiry |
VWF-2643M | Recombinant Mouse VWF Protein (1498-1665 aa), His-Myc-tagged | +Inquiry |
◆ Native Protein | ||
VWF-17H | Native Human von Willebrand Factor, Factor VIII Free | +Inquiry |
VWF-369H | Native Human Von Willebrand Factor | +Inquiry |
◆ Lysates | ||
VWF-001HCL | Recombinant Human VWF cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThere is currently no treatment that directly targets the VWF protein. However, some medications can improve the patient's clotting status and reduce the risk of bleeding. For example, the use of recombinant human coagulation factor VIII. can replace the deficient factor VIII and improve coagulation function. In addition, the use of antifibrinolytic drugs can inhibit the degradation of fibrin and maintain the stability of the coagulation process.
VWF protein is closely related to coagulation factor VIII. Coagulation factor VIII. is a serine protease that plays a key role in the coagulation process. VWF protein can act as a cofactor for coagulation factor VIII., accelerating the coagulation process. In addition, VWF protein can also inhibit the activity of plasminogen activators, thereby inhibiting the degradation of fibrin and maintaining the stability of the coagulation process.
In the process of hemostasis, the role of VWF protein is mainly to promote platelet adhesion and aggregation. When platelets bind to VWF protein, morphological changes occur and the phospholipid surface is exposed, which interacts with other platelets or endothelial cells to form platelet thrombosis and play a hemostatic role.
There is a complex interaction between VWF protein and other coagulation factors. For example, VWF proteins can bind to glycoprotein II.b/III.a receptors on the surface of platelets, promoting platelet adhesion and aggregation.
Genetic variations in the VWF protein can lead to coagulation disorders such as von Willebrand disease (VWD). Some variants can cause VWF protein deficiency or dysfunction, which can affect the ability of platelets to adhere and aggregate, increasing the risk of bleeding. Understanding these variants can help diagnose and classify different subtypes of VWD.
The main function of VWF protein in blood is to promote platelet adhesion and aggregation, thereby participating in the process of hemostasis and coagulation. In addition, VWF protein can also act as a regulator of endothelial cells and participate in the repair and remodeling of blood vessel walls.
Customer Reviews (3)
Write a reviewStrong activity, a small amount can play a role, save reagents.
It has been used in experiments, and the results are accurate and reliable.
No significant difference was found between different batches, and the repeatability between batches was good.
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