Recombinant Human SCO1

• Cat.No.: SCO1-168H
• Product Overview: Recombinant Sco1 was cloned from Human cDNA with the mutation P174L and expressed inE.coli. The protein consists of the full length soluble domain of the apo-HSco1SH (aa1 32-301) lacking the transmembrane segment (NCBI accession NP_004580). Four additional aa (GSFT) are present at the N-term end of the protein. MW = 19.7 kDa.

Specification

• Cat. No.: SCO1-168H
• Description: Protein SCO1 homolog, mitochondrial is a protein that in humans is encoded by the SCO1 gene. Mammalian cytochrome coxidase (COX) catalyzes the transfer of reducing equivalents from cytochromec to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochromecoxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene.
• Source: E.Coli.
• Purity: > 95% by SDS-PAGE. The protein was observed as a single band migrating around 20KDa.
• Supplied AS: Solution of Apo-protein in in 50Mm KH2PO4/K2HPO4, pH7.2, 1Mm DTT. The concentration is calculated from the absorbance at 280nm. (ε280 = 20525 M-1cm-1).
• Characteristics: Under the above described conditions, to avoid precipitation or protein dimerization, the product can be concentrated to a maximum of 1.4mM underInert atmosphere.
• Storage: -20°C. The protein is stable at 4°C for at least 2 weeks and at 25°C for at least some days. After initial defrost, aliquot protein into individual tubes and refreeze at -20°C. Avoid repeated freeze/defrost cycles.

Gene Information

• Gene Name: SCO1 SCO cytochrome oxidase deficient homolog 1 (yeast) [ Homo sapiens ]
• Synonyms: SCO1; SCO cytochrome oxidase deficient homolog 1 (yeast); SCOD1; SCO (cytochrome oxidase deficient, yeast) homolog 1;Protein SCO1 homolog, mitochondrial;cytochrome oxidase deficient homolog
• Gene ID: 6341
• mRNA Refseq: NM_004589
• Protein Refseq: NP_004580
• MIM: 603644
• UniProt ID: O75880
• Chromosome Location: 17p13.1
• Function: copper ion binding;metal ion binding