Recombinant Human IL5
Cat.No. : | IL5-125H |
Product Overview : | Recombinant Human interleukin 5 (colony-stimulating factor, eosinophil) sequence (containing the signal peptide sequence, and the mature human Interleukin 5 sequence) was expressed in modifiedhuman 293 cells. |
- Specification
- Gene Information
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Cat. No. : | IL5-125H |
Description : | Interleukin 5 (IL-5) plays an important role in B cell development by inducing the terminal differentiation of late-developing B cells. Additionally, IL-5 regulates the differentiation, survival and degranulation of eosinophils. IL-5 is expressed predominately by T-lymphocytes and mast cells, and to a lesser extent by eosinophils, natural killer cells and endothelial cells. |
Source : | Human 293 cells. |
Amino Acid Sequence : | IPTEIPTSALVK ETLALLSTHR TLLIANET LRIPVPVH KNHQLCTEE IFQGIGTLES QTVQGG TVE RL FKN LSLI K KYIDGQKK KCGEERRRV NQFLDYLQE FLG VMN TEWIIES. |
Molecular Mass : | IL-5 migrates as a broad band between 15 and 20 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation. This compares with the unmodified IL-5 that has a predicted molecular mass of 13.1 kDa. |
PI : | IL-5 separates into a number of isoforms with a pI between 4.8 and 7.7 in 2D PAGE due to post-translational modifications, in particular glycosylation. This compares with the unmodified IL-5 that has a predicted pI of 7.02. |
% Carbohydrate : | Purified IL-5 consists of 10-35% carbohydrate by weight. |
Glycosylation : | IL-5 has N-linked and O-linked oligosaccharides. |
Purity : | >95%, as determined by SDS-PAGE and visualized by silver stain. |
Formulation : | When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose. |
Reconstitution : | It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. |
Storage : | Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended. |
Gene Name : | IL5 interleukin 5 (colony-stimulating factor, eosinophil) [ Homo sapiens ] |
Synonyms : | IL5; interleukin 5 (colony-stimulating factor, eosinophil); EDF; IL-5; TRF; B cell differentiation factor I; T-cell replacing factor; eosinophil differentiation factor; interleukin 5; interleukin-5; B-cell differentiation factor I; Eosinophil differentiation factor; OTTHUMP00000065830 |
Gene ID : | 3567 |
mRNA Refseq : | NM_000879 |
Protein Refseq : | NP_000870 |
MIM : | 147850 |
UniProt ID : | P05113 |
Chromosome Location : | 5q31.1 |
Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Hematopoietic cell lineage; Allograft rejection; Asthma; Autoimmune thyroid disease; Fc epsilon RI signaling pathway; T cell receptor signaling pathway |
Function : | interleukin-5 receptor activity; cytokine activity; growth factor activity |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionInhibit the creatinine kinase level in the blood of patients with tuberous sclerosis, reduce the inflammatory response, and improve the quality of life of patients.
IL5 can reduce the number of eosinophils in the nasal mucosa of patients with allergic rhinitis, reducing the symptoms of allergic reactions, such as sneezing, runny nose and nasal congestion.
Stimulate the proliferation and differentiation of white blood cells, promote the function of the immune system, and is used to treat diseases such as asthma, allergic rhinitis, nodular sclerosis and some malignant tumors.
Cause mild side effects such as headache, nausea, vomiting, and serious side effects such as allergic reactions if the dose is too large or allergic.
IL5 cannot be administered orally, only by injection or intravenous drip.
IL5 can reduce the number of eosinophils in the lungs of asthma patients, reduce the frequency and severity of asthma attacks, and improve the quality of life of patients.
Customer Reviews (3)
Write a reviewHigh efficacy and safety in clinical treatment.
There are no structural or functional defects.
The stability and activity are maintained well during long-term storage.
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