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Recombinant Human IL5

Cat.No. : IL5-125H
Product Overview : Recombinant Human interleukin 5 (colony-stimulating factor, eosinophil) sequence (containing the signal peptide sequence, and the mature human Interleukin 5 sequence) was expressed in modifiedhuman 293 cells.
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  • Gene Information
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Cat. No. : IL5-125H
Description : Interleukin 5 (IL-5) plays an important role in B cell development by inducing the terminal differentiation of late-developing B cells. Additionally, IL-5 regulates the differentiation, survival and degranulation of eosinophils. IL-5 is expressed predominately by T-lymphocytes and mast cells, and to a lesser extent by eosinophils, natural killer cells and endothelial cells.
Source : Human 293 cells.
Amino Acid Sequence : IPTEIPTSALVK ETLALLSTHR TLLIANET LRIPVPVH KNHQLCTEE IFQGIGTLES QTVQGG TVE RL FKN LSLI K KYIDGQKK KCGEERRRV NQFLDYLQE FLG VMN TEWIIES.
Molecular Mass : IL-5 migrates as a broad band between 15 and 20 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation. This compares with the unmodified IL-5 that has a predicted molecular mass of 13.1 kDa.
PI : IL-5 separates into a number of isoforms with a pI between 4.8 and 7.7 in 2D PAGE due to post-translational modifications, in particular glycosylation. This compares with the unmodified IL-5 that has a predicted pI of 7.02.
% Carbohydrate : Purified IL-5 consists of 10-35% carbohydrate by weight.
Glycosylation : IL-5 has N-linked and O-linked oligosaccharides.
Purity : >95%, as determined by SDS-PAGE and visualized by silver stain.
Formulation : When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Reconstitution : It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Storage : Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
Gene Name : IL5 interleukin 5 (colony-stimulating factor, eosinophil) [ Homo sapiens ]
Synonyms : IL5; interleukin 5 (colony-stimulating factor, eosinophil); EDF; IL-5; TRF; B cell differentiation factor I; T-cell replacing factor; eosinophil differentiation factor; interleukin 5; interleukin-5; B-cell differentiation factor I; Eosinophil differentiation factor; OTTHUMP00000065830
Gene ID : 3567
mRNA Refseq : NM_000879
Protein Refseq : NP_000870
MIM : 147850
UniProt ID : P05113
Chromosome Location : 5q31.1
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Hematopoietic cell lineage; Allograft rejection; Asthma; Autoimmune thyroid disease; Fc epsilon RI signaling pathway; T cell receptor signaling pathway
Function : interleukin-5 receptor activity; cytokine activity; growth factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Which effect of IL5 in the treatment of tuberous sclerosis? 08/07/2022

Inhibit the creatinine kinase level in the blood of patients with tuberous sclerosis, reduce the inflammatory response, and improve the quality of life of patients.

Does there have any effect of IL5 in the treatment of allergic rhinitis? 07/07/2022

IL5 can reduce the number of eosinophils in the nasal mucosa of patients with allergic rhinitis, reducing the symptoms of allergic reactions, such as sneezing, runny nose and nasal congestion.

What is the main function of IL5? 03/04/2022

Stimulate the proliferation and differentiation of white blood cells, promote the function of the immune system, and is used to treat diseases such as asthma, allergic rhinitis, nodular sclerosis and some malignant tumors.

Does IL5 have side effects? 10/26/2019

Cause mild side effects such as headache, nausea, vomiting, and serious side effects such as allergic reactions if the dose is too large or allergic.

Can IL5 be administered orally? 07/24/2019

IL5 cannot be administered orally, only by injection or intravenous drip.

What is the effect of IL5 in the treatment of asthma? 02/14/2019

IL5 can reduce the number of eosinophils in the lungs of asthma patients, reduce the frequency and severity of asthma attacks, and improve the quality of life of patients.

Customer Reviews (3)

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Reviews
07/26/2022

    High efficacy and safety in clinical treatment.

    06/22/2022

      There are no structural or functional defects.

      01/31/2019

        The stability and activity are maintained well during long-term storage.

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