Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-048-3343   Email: info@creative-biomart.com
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Recombinant Human CCL5 protein

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Fc(3)
His(5)
MYC/DDK(1)
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Cat.No.:
CCL5-81H
Product Overview:
Recombinant Human CCL5 was expressed in HEK293.
Description:
Chemokine (C-C motif) ligand 5(CCL5), also known as RANTES (Regulated upon activation, Normal T cell Expressed and presumable Secreted) is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. RANTES is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes in inflammatory sites. With the help of specific cytokines (i.e., IL-2 and IFN-γ) that are released by T cells, RANTES induces the proliferation and activation of certain natural-killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. RANTES is also an HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans. It has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV).
Source:
HEK293
Species:
Human
Form:
Lyophilized after extensive dialysis against PBS.
Bio-activity:
The EC50 value of human RANTES/CCL5 on Ca2+ mobilization assay in CHO-K1/Gα15/hCCR1 cells (human Gα15 and human CCR1 stably expressed in CHO-K1 cells) is less than 0.2 μg/ml.
Molecular Mass:
8 kDa, observed by reducing SDS-PAGE.
Protein length:
68 amino acids
AA Sequence:
SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS
Endotoxin:
< 0.2 EU/μg, determined by LAL method.
Purity:
> 98% as analyzed by SDS-PAGE.
Storage:
Lyophilized recombinant human RANTES/CCL5 remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, human RANTES/CCL5 should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade
Reconstitution:
Reconstituted in ddH2O or PBS at 100 μg/ml.


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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