Recombinant Human Glutathione S-transferase Theta 1, His-tagged

• Cat.No.: GSTT1-180H
• Product Overview: Recombinant human GSTT1, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography. MW =31.5 kDa (277aa).

Specification

• Cat. No.: GSTT1-180H
• Description: Glutathione S-transferase theta 1(GSTT1) is one of the GSTs' four main classes: alpha, mu, pi, theta. This enzyme is involved in activation and detoxification reactions and catalyzes the conjugation of industrial chemicals, e.g. epoxybutane, ethylene oxides, halomethane with glutathione.The absence of the GSTTI enzyme, might determine the individual risk for development of acquired aplastic anemia and acute myeloid leukemia.
• Source: E.coli.
• Amino Acid Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMGL ELYLDLLSQP CRAVYIFAKK NDIPFELRIV DLIKGQHLSD ACAQVNPLKK VPALKDGDFT LTESVAILLY LTRKYKVPDY WYPQDLQARA RVDEYLAWQH TTLRRSCLRA LWHKVMFPVF LGEPVSPQTL AATLAELDVT LQLLEDKFLQ NKAFLTGPHI SLADLVAITE LMHPVGAGCQ VFEGRPKLAT WRQRVEAAVG EDLFQEAHEV ILKAKDFPPA DPTIKQKLMP WVLAMIR.
• Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: GSTT1 glutathione S-transferase theta 1 [ Homo sapiens ]
• Synonyms: GSTT1; glutathione S-transferase theta 1; EC 2.5.1.18;Glutathione S-transferase theta-1; GST class-theta-1; Glutathione transferase T1-1
• Gene ID: 2952
• mRNA Refseq: NM_000853
• Protein Refseq: NP_000844
• MIM: 600436
• UniProt ID: P30711
• Chromosome Location: 22q11.23
• Pathway: Drug metabolism - cytochrome P450; Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450
• Function: glutathione transferase activity; transferase activity