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Recombinant Human Non-metastatic Cells 1, Protein (NM23A)

Cat.No. : NME1-485H
Product Overview : Recombinant human NME1 was expressed inE.coliand purified by using conventional chromatography techniques. MW = 17.1 kDa (152aa).
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Cat. No. : NME1-485H
Description : Non-metastatic cells 1 (NME1), also known as NM23-H1, originally identified as a candidate metastasis suppressor gene. NME1 is expressed in different tumor types where their levels have been alternatively associated with reduced or increased metastatic potential. Reductions in NME1 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas. On the contrary, high levels of NME1 gene expression are noted in the advanced stage of thyroid carcinomas.
Source : E.coli.
Amino Acid Sequence : MANCERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF MQASEDLLKE HYVDLKDRPF FAGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVESAEKEI GLWFHPEELV DYTSCAQNWI YE.
Form : Liquid. In 20mM Tris-HCl buffer (pH7.5) containing 1mM DTT,10% glycerol.
Purity : > 95% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Endotoxin Level : < 1.0 EU per 1 μg of protein (determined by LAL method ).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : NME1 non-metastatic cells 1, protein (NM23A) expressed in [ Homo sapiens ]
Synonyms : NME1; non-metastatic cells 1, protein (NM23A) expressed in; NB; AWD; NBS; GAAD; NM23; NDPKA; NDPK-A; NM23-H1; NDP kinase A; OTTHUMP00000174772; EC 2.7.4.6; NDK A; Tumor metastatic process-associated protein; Metastasis inhibition factor nm23; nm23-H1; Granzyme A-activated DNase
Gene ID : 4830
mRNA Refseq : NM_000269
Protein Refseq : NP_000260
MIM : 156490
UniProt ID : P15531
Chromosome Location : 17q21.33
Pathway : Metabolic pathways; Purine metabolism; Metablism of nucleotid
Function : ATP binding; GTP binding; deoxyribonuclease activity; gamma-tubulin binding; identical protein binding; kinase activity; magnesium ion binding; nucleoside diphosphate kinase activity; nucleotide binding; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does NME1 play in DNA repair and the maintenance of genomic stability? 12/05/2022

NME1 plays a role in DNA repair, contributing to genomic stability.

How does NME1 influence signal transduction in response to cellular stress? 01/30/2022

NME1 modulates cellular responses to stress, affecting signal transduction pathways.

What is the impact of NME1 on apoptosis and cell survival pathways? 05/09/2020

NME1 influences apoptosis and cell survival, impacting cell fate decisions.

How do alterations in NME1 expression or activity affect drug resistance in cancer therapy? 11/05/2019

Changes in NME1 can impact drug resistance in cancer, affecting treatment efficacy.

What are the mechanisms by which NME1 modulates the immune response, especially in tumor immunity? 10/21/2018

NME1 regulates the immune response, particularly in tumor immunity.

How does NME1 contribute to the metastatic potential of cancer cells? 07/03/2018

NME1 affects the metastatic behavior of cancer cells, influencing their spread.

How does NME1 regulate nucleotide metabolism and cellular energy balance? 04/20/2018

NME1 is involved in nucleotide metabolism, crucial for maintaining cellular energy balance.

Customer Reviews (3)

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Reviews
04/02/2022

    Critical expertise in protein engineering, unmatched in quality.

    10/28/2021

      Reliable protein crystallization services, consistently yields exceptional results.

      12/23/2018

        Efficient protein purification, consistent yields, cost-effective for research.

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