Recombinant Human Non-metastatic Cells 1, Protein (NM23A)
Cat.No. : | NME1-485H |
Product Overview : | Recombinant human NME1 was expressed inE.coliand purified by using conventional chromatography techniques. MW = 17.1 kDa (152aa). |
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- Gene Information
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Cat. No. : | NME1-485H |
Description : | Non-metastatic cells 1 (NME1), also known as NM23-H1, originally identified as a candidate metastasis suppressor gene. NME1 is expressed in different tumor types where their levels have been alternatively associated with reduced or increased metastatic potential. Reductions in NME1 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas. On the contrary, high levels of NME1 gene expression are noted in the advanced stage of thyroid carcinomas. |
Source : | E.coli. |
Amino Acid Sequence : | MANCERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF MQASEDLLKE HYVDLKDRPF FAGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVESAEKEI GLWFHPEELV DYTSCAQNWI YE. |
Form : | Liquid. In 20mM Tris-HCl buffer (pH7.5) containing 1mM DTT,10% glycerol. |
Purity : | > 95% by SDS – PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Endotoxin Level : | < 1.0 EU per 1 μg of protein (determined by LAL method ). |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | NME1 non-metastatic cells 1, protein (NM23A) expressed in [ Homo sapiens ] |
Synonyms : | NME1; non-metastatic cells 1, protein (NM23A) expressed in; NB; AWD; NBS; GAAD; NM23; NDPKA; NDPK-A; NM23-H1; NDP kinase A; OTTHUMP00000174772; EC 2.7.4.6; NDK A; Tumor metastatic process-associated protein; Metastasis inhibition factor nm23; nm23-H1; Granzyme A-activated DNase |
Gene ID : | 4830 |
mRNA Refseq : | NM_000269 |
Protein Refseq : | NP_000260 |
MIM : | 156490 |
UniProt ID : | P15531 |
Chromosome Location : | 17q21.33 |
Pathway : | Metabolic pathways; Purine metabolism; Metablism of nucleotid |
Function : | ATP binding; GTP binding; deoxyribonuclease activity; gamma-tubulin binding; identical protein binding; kinase activity; magnesium ion binding; nucleoside diphosphate kinase activity; nucleotide binding; transferase activity |
Products Types
◆ Recombinant Protein | ||
NME1-1519H | Recombinant Human NME1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NME1-5924H | Recombinant Human NME1 Protein, GST-tagged | +Inquiry |
NME1-2873R | Recombinant Rhesus Macaque NME1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NME1-3662R | Recombinant Rat NME1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NME1-6108M | Recombinant Mouse NME1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
NME1-3792HCL | Recombinant Human NME1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionNME1 plays a role in DNA repair, contributing to genomic stability.
NME1 modulates cellular responses to stress, affecting signal transduction pathways.
NME1 influences apoptosis and cell survival, impacting cell fate decisions.
Changes in NME1 can impact drug resistance in cancer, affecting treatment efficacy.
NME1 regulates the immune response, particularly in tumor immunity.
NME1 affects the metastatic behavior of cancer cells, influencing their spread.
NME1 is involved in nucleotide metabolism, crucial for maintaining cellular energy balance.
Customer Reviews (3)
Write a reviewCritical expertise in protein engineering, unmatched in quality.
Reliable protein crystallization services, consistently yields exceptional results.
Efficient protein purification, consistent yields, cost-effective for research.
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