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Recombinant Human Threonyl-tRNA Synthetase, His-tagged

Cat.No. : TARS-217H
Product Overview : Recombinant Human PL-7 produced inSf9is a glycosylated, polypeptide chain having a molecular mass of 83,312 dalton. Recombinant PL-7 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.
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Cat. No. : TARS-217H
Description : Threonyl-tRNA synthetase is a member of the aminoacyl-tRNA synthetase family, key enzymes of protein biosynthesis which charge tRNA molecules with the respective amino acids. This 83 kDa protein is an autoantigen recognized by PL-7 antibodies which occur in a subset of patients with polymyositis and dermatomyositis. Preliminary data suggest that PL-7 antibodies (similar to Jo-1 antibodies) indicate an increased risk for lung involvement, but this needs to be confirmed for a larger number of cases.
Source : Sf9 insect cells.
Physical Appearance : Sterile Filtered clear soultion.
Formulation : Recombinant Human PL-7 is supplied at a of 0.5 mg/ml in 20mM HEPES buffer pH-8, 200mM sodium chloride, and 20% glycerol.
Stability : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze-thaw cycles.
Purity : Greater than 95% (SDS-PAGE).
Immunological Functions : 1. Binds IgG-type human auto-antibodies. 2. Standard ELISA test (checker-board analysis of positive/negative sera panels immuno-dot test).
Applications : Western-Blot with monoclonal anti-hexa-His-tag antibody & Polymyositis sera.
Coating Concentration : 0.3-0.8 µg/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination.
Gene Name : TARS threonyl-tRNA synthetase [ Homo sapiens ]
Synonyms : TARS; threonyl-tRNA synthetase; ThrRS; MGC9344; Threonyl-tRNA synthetase, cytoplasmic; Threonine--tRNA ligase; EC 6.1.1.3; threonine tRNA ligase 1, cytoplasmic
Gene ID : 1158
mRNA Refseq : NM_152295
Protein Refseq : NP_689508
MIM : 187790
UniProt ID : P26639
Chromosome Location : 5p13.2
Pathway : Aminoacyl-tRNA biosynthesis; Gene Expression
Function : ATP binding; ligase activity; nucleotide binding; protein binding; protein homodimerization activity; threonine-tRNA ligase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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