Recombinant Human TANK

• Cat.No.: TANK-517H
• Product Overview: Recombinant human TANK protein was expressed inE.coliand purified by using conventional chromatography techniques. 13.6 kDa (119 aa).

Specification

• Cat. No.: TANK-517H
• Description: TANK, also known as TRAF(tumor necrosis factor receptor-associated Factor)-interacting protein, is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby proposing that this protein is an inhibitor of TRAF function that regulates TRAF protein activity by sequestering TRAFs in a latent state in the cytoplasm. Overexpression of TANK inhibits TRAF2-mediated NF-Kappa-B activation signaled by CD40 and both TNF receptors and inhibits LMP1-mediated NF-kappa-B activation by blocking the association of TRAF2 with LMP1.
• Source: E.coli.
• Amino Acid Sequence: MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKS QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS GIAREKLPKV DIA SAESSI.
• Form: Liquid. In 20mM Tris-HCl buffer (pH8.0).
• Purity: > 90% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: TANK TRAF family member-associated NFKB activator [ Homo sapiens ]
• Synonyms: TANK; TRAF family member-associated NFKB activator; TRAF2; I-TRAF;TRAF interacting protein TANK; TRAF family member-associated NF-KAPPA-B activator; TRAF-interacting protein; I-TRAF; TRAF interacting protein
• Gene ID: 10010
• mRNA Refseq: NM_004180
• Protein Refseq: NP_004171
• MIM: 603893
• UniProt ID: Q92844
• Chromosome Location: 2q24-q31
• Pathway: RIG-I-like receptor signaling pathway
• Function: metal ion binding; protein binding; zinc ion binding