Recombinant Human Parathyroid Hormone

• Cat.No.: PTH-83H
• Product Overview: Recombinant Human parathyroid hormone(amino acids 32-115) was overexpressed inE.coliand purified to apparent homogeneity by using conventional column chromatography techniques. MW = 9.55 kDa (85 aa).

Specification

• Cat. No.: PTH-83H
• Description: Human parathyroid hormone(hPTH) is an 84 amino acid residue peptide and one of the main regulators in maintenance of calcium homeostasis. It acts primarily on kidney and bone cells stimulating calcium back resorption or calcium mobilization, respectively. The whole mechanism is still under discussion, but low-dose hPTH triggers cyclic AMP-dependent protein kinase in some populations of bone cells bearing PTH receptors, which stimulates the proliferation of osteoblasts.
• Source: E.coli.
• Amino Acid Sequence: MSVSEIQLMH NLGKHLNSME RVEWLRKKLQ DVHNFVALGA PLAPRDAGSQ RPRKKEDNVL VESHEKSLGE ADKADVNVLT KAKSQ.
• Form: Liquid. In phosphate-buffered Saline(pH 7.4).
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: PTH parathyroid hormone [ Homo sapiens ]
• Synonyms: parathormone; parathyrin, Parathyroid hormone Precursor; PTH1; PTH; parathyroid hormone; parathyroid hormone 1
• Gene ID: 5741
• mRNA Refseq: NM_000315
• Protein Refseq: NP_000306
• MIM: 168450
• UniProt ID: P01270
• Chromosome Location: 11p15.3-p15.1
• Pathway: Neuroactive ligand-receptor interaction
• Function: hormone activity; parathyroid hormone receptor binding activity