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Recombinant Human Superoxide Dismutase 1

Cat.No. : SOD1-200H
Product Overview : Recombinant Human superoxide dismutase 1 was expressed inE.coliand purified by conventional chromatography techniques. MW=15.9kDa (154 aa).
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Cat. No. : SOD1-200H
Description : Superoxide dismutase 1(SOD1) binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals in the body. The encoded protein neutralizes supercharged oxygen molecules, which can damage cells if their levels are not controlled. Mutations in SOD1 cause a form of familial amyotrophic lateral sclerosis (ALS).
Source : Escherichia Coli.
Amino Acids Sequences : MATKAVCVLK GDGPVQGIIN FEQKESNGPV KVWGSIKGLT EGLHGFHVHE FGDNTAGCTS AGPHFNPLSR KHGGPKDEER HVGDLGNVTA DKDGVADVSI EDSVISLSGD HCIIGRTLVV HEKADDLGKG GNEESTKTGN AGSRLACGVI GIAQ
Purity : > 95% by SDS-PAGE.
Concentration : 1mg/ml (determined by Bradford assay).
Form : Liquid. In 20mM Tris-HCl buffer (pH7.5) containing 10% glycerol.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : SOD1 superoxide dismutase 1, soluble [ Bos taurus ]
Synonyms : SOD1; SOD1L1; superoxide dismutase 1, soluble; superoxide dismutase 1, soluble; superoxide dismutase 1, soluble; Cu-Zn superoxide dismutase; superoxide dismutase 1, soluble-like; ALS; ALS1; EC 1.15.1.1;IPOA;Cu,Zn superoxide dismutase, EC 1.15.1.1; Cu/Zn superoxide dismutase; SOD, soluble; amyotrophic lateral sclerosis 1 (adult); indophenoloxidase A; superoxide dismutase (aa 120-154); superoxide dismutase 1, soluble; superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)); superoxide dismutase, cystolic
Gene ID : 281495
mRNA Refseq : NM_174615
Protein Refseq : NP_777040
MIM : P00442
UniProt ID : P00441
Chromosome Location : 1q12-q14
Pathway : Amyotrophic lateral sclerosis (ALS); Neurodegenerative Disorders
Function : antioxidant activity; chaperone binding; copper ion binding; metal ion binding; oxidoreductase activity; protein phosphatase 2B binding; superoxide dismutase activity; zinc ion binding.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there potential therapeutic strategies targeting SOD1 for disease treatment? 01/23/2022

Therapeutic strategies may involve modulating SOD1 activity or expression to mitigate oxidative stress-related damage.

What is the primary biological function of SOD1 in cells? 01/03/2022

SOD1 acts as an antioxidant, converting superoxide radicals to hydrogen peroxide and oxygen.

What are the genetic implications of mutations in the SOD1 gene? 03/01/2021

Mutations in SOD1 can result in loss or gain of function, contributing to disease development.

How is SOD1 implicated in neurodegenerative diseases? 02/09/2020

SOD1 mutations are implicated in Amyotrophic Lateral Sclerosis (ALS), leading to neurodegeneration.

In which cellular compartments is SOD1 primarily located? 11/14/2019

SOD1 is primarily located in the cytoplasm and mitochondrial intermembrane space.

What role does SOD1 play in maintaining cellular redox balance? 08/27/2019

It helps maintain cellular redox balance, protecting cells from oxidative damage.

How does SOD1 contribute to the cellular antioxidant defense system? 02/27/2019

It plays a crucial role in cellular defense against oxidative stress.

Customer Reviews (3)

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Reviews
11/15/2022

    Worked perfectly, no problems.

    10/09/2020

      Quick delivery, fantastic product.

      10/02/2020

        Reliable results every time.

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