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Active Recombinant Human MMP13 protein

Cat.No. : MMP13-159H
Product Overview : Recombinant Human MMP13(Tyr104-Asn274) with a C-terminal purification tag was expressed in E. coli.
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  • Gene Information
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Description : Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Source : E. coli
Species : Human
Form : Liquid. In 50mM TRIS, 5mM CaCl2, 300mM NaCl, 20µM ZnCl2, 0.5% Brij-35, and 30% glycerol.
Bio-activity : ≥100 U/µg
Molecular Mass : 20.4 kDa
Purity : ≥95% (SDS-PAGE)
Unit Definition : One U=100 pmol/min at 37 centigrade using the colorimetric thiopeptolide Ac-Pro-Leu-Gly-S-Leu-Leu-Gly-OEt as substrate.
Applications : Useful tool to study enzyme kinetics, cleave target substrates, and screen for inhibitors.
Storage : Store at –80 centigrade
Gene Name : MMP13 matrix metallopeptidase 13 (collagenase 3) [ Homo sapiens ]
Official Symbol : MMP13
Synonyms : MMP13; matrix metallopeptidase 13 (collagenase 3); matrix metalloproteinase 13 (collagenase 3); collagenase 3; CLG3; MMP-13; MANDP1;
Gene ID : 4322
mRNA Refseq : NM_002427
Protein Refseq : NP_002418
MIM : 600108
UniProt ID : P45452
Chromosome Location : 11q22.3
Pathway : Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem;
Function : calcium ion binding; calcium-dependent protein binding; fibronectin binding; low-density lipoprotein particle receptor binding; metalloendopeptidase activity; peptidase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can MMP13 be a potential therapeutic target for cancer treatment? 04/17/2023

Yes, targeting MMP13 has been explored as a potential therapeutic strategy to inhibit cancer metastasis and invasion.

Is MMP13 involved in cardiovascular diseases? 05/29/2022

Yes, MMP13 has been implicated in cardiovascular diseases by contributing to the remodeling of blood vessels and cardiac tissues.

How does MMP13 contribute to cancer progression? 11/18/2021

MMP13 facilitates tumor invasion and metastasis by breaking down the extracellular matrix and promoting the migration of cancer cells.

How is genetic variation in MMP13 associated with disease susceptibility? 03/03/2019

Certain genetic variations in the MMP13 gene have been linked to increased susceptibility to diseases such as osteoarthritis and cancer.

Are there any clinical trials targeting MMP13? 08/30/2017

Some clinical trials are investigating drugs that specifically target MMP13 in various cancer types to assess their efficacy and safety.

Customer Reviews (3)

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Reviews
12/05/2022

    Its reliability and versatility make it an essential tool for investigating MMP13 protein's expression, function, and structural characteristics.

    07/27/2020

      The use of MMP13 protein in this technique allows researchers to explore the intricate three-dimensional structure of the protein at a molecular level.

      10/13/2016

        MMP13 protein is highly recommended for researchers due to its excellent performance in WB experiments and its utility in protein electron microscopy structure analysis.

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